CAS 111682-13-4

N-(4-Methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-[(1S)-3-chloro-1-methyl-2-oxopropyl]-L-prolinamide

Description:

N-(4-Methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-[(1S)-3-chloro-1-methyl-2-oxopropyl]-L-prolinamide, with CAS number 111682-13-4, is a synthetic compound that belongs to the class of peptides and peptide derivatives. This substance features a complex structure characterized by multiple functional groups, including amide linkages and a methoxy group, which contribute to its chemical reactivity and potential biological activity. The presence of chiral centers indicates that the compound may exhibit stereoisomerism, which can influence its pharmacological properties. Typically, compounds of this nature are investigated for their potential applications in medicinal chemistry, particularly in the development of therapeutic agents. The specific interactions and mechanisms of action would depend on its conformation and the presence of substituents that can engage in hydrogen bonding or other intermolecular interactions. As with many synthetic peptides, stability, solubility, and bioavailability are critical factors that would be assessed during research and development.

Formula: C₂₀H₃₁ClN₄O₇

InChI: InChI=1S/C20H31ClN4O7/c1-11(15(26)10-21)23-19(30)14-6-5-9-25(14)20(31)13(3)24-18(29)12(2)22-16(27)7-8-17(28)32-4/h11-14H,5-10H2,1-4H3,(H,22,27)(H,23,30)(H,24,29)/t11-,12-,13-,14-/m0/s1

InChI key: InChIKey=UIYRKMRXXFXSTH-XUXIUFHCSA-N

SMILES: C([C@@H](NC([C@@H](NC(CCC(OC)=O)=O)C)=O)C)(=O)N1[C@H](C(N[C@H](C(CCl)=O)C)=O)CCC1

Synonyms:

• <span class="text-smallcaps">L</smallcap>-Prolinamide, N-(4-methoxy-1,4-dioxobutyl)-<smallcap>L</smallcap>-alanyl-<smallcap>L</span>-alanyl-N-(3-chloro-1-methyl-2-oxopropyl)-, (S)-
• <span class="text-smallcaps">L</smallcap>-Prolinamide, N-(4-methoxy-1,4-dioxobutyl)-<smallcap>L</smallcap>-alanyl-<smallcap>L</span>-alanyl-N-[(1S)-3-chloro-1-methyl-2-oxopropyl]-
• Elastase inhibitor II
• L-Prolinamide, N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-(3-chloro-1-methyl-2-oxopropyl)-, (S)-
• Methoxysuccinyl-alanyl-alanyl-prolyl-alanine chloromethyl ketone
• Msack
• N-(4-Methoxy-1,4-dioxobutyl)-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>L</smallcap>-alanyl-N-[(1S)-3-chloro-1-methyl-2-oxopropyl]-<smallcap>L</span>-prolinamide
• N-(4-methoxy-4-oxobutanoyl)-L-alanyl-N-({(2S)-1-[(1S)-3-chloro-1-methyl-2-oxopropyl]pyrrolidin-2-yl}carbonyl)-L-alaninamide
• L-Prolinamide, N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-[(1S)-3-chloro-1-methyl-2-oxopropyl]-
• N-(4-Methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-[(1S)-3-chloro-1-methyl-2-oxopropyl]-L-prolinamide

MeOSuc-Ala-Ala-Pro-Ala-chloromethylketone

CAS: 111682-13-4

MeOSuc-AAPA-CMK, inhibitor of human neutrophil elastase. The structure of the enzyme-inhibitor complex at 1.84 Å resolution reveals crosslinking of the catalytic residues His-57 and Ser-195 by the peptidyl chloromethylketone.

Formula: C₂₀H₃₁ClN₄O₇

Purity: > 99%

Color and Shape: White Powder

Molecular weight: 474.94

Ref: 01-4012071

MeOSuc-Ala-Ala-Pro-Ala-chloromethylketone

CAS: 111682-13-4

MeOSuc-Ala-Ala-Pro-Ala-chloromethylketone is a peptidyl substrate for the enzyme carboxypeptidase A. This substrate has a high specificity for carboxypeptidase A and does not bind to other enzymes such as carboxypeptidase B, D, or L. The hydrophobic nature of this substrate has been shown in both hamsters and macaques. MeOSuc-Ala-Ala-Pro-Ala-chloromethylketone also shows cardiovascular effects in both animal models. It is possible that this effect is due to the proteolytic activity of the enzyme. More research needs to be done to identify the sequence of this peptide and how it may affect humans.

Formula: C₂₀H₃₁ClN₄O₇

Purity: Min. 95%

Molecular weight: 474.94 g/mol

Ref: 3D-FM111029

MeO-Suc-Ala-Ala-Pro-Ala-CMK

CAS: 111682-13-4

MeO-Suc-Ala-Ala-Pro-Ala-CMK (MSACK) is an inhibitor of human neutrophil elastase (HNE) with an IC50 of 20.3 μM. It effectively inhibits the hydrolysis of substrates like lung tissue elastin by HNE and is applicable in studies related to conditions such as chronic obstructive pulmonary disease (COPD).

Formula: C₂₀H₃₁ClN₄O₇

Color and Shape: Solid

Molecular weight: 474.936

Ref: TM-T206832