Description:Trimethylsilyl isocyanate (TMS-IC) is a chemical compound characterized by the presence of a trimethylsilyl group attached to an isocyanate functional group. Its molecular formula is typically represented as C5H11NOSi. This compound is a colorless to pale yellow liquid with a distinctive odor, and it is known for its reactivity, particularly in the presence of moisture, which can lead to hydrolysis and the formation of isocyanic acid and trimethylsilanol. TMS-IC is utilized in organic synthesis, particularly in the derivatization of alcohols and amines, enhancing their volatility and stability for analysis. It is also employed in the preparation of various silicon-containing compounds. Due to its isocyanate functionality, it can be hazardous, necessitating careful handling to avoid exposure, as it may cause irritation to the skin, eyes, and respiratory system. Proper storage in a cool, dry place away from moisture is essential to maintain its stability and reactivity.
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