CAS 111869-49-9

7-Deaza-ddG

Description:

7-Deaza-ddG, or 7-Deaza-2'-deoxyguanosine, is a modified nucleoside analog that is often used in molecular biology and biochemistry research. Its structure features a deazaguanine base, which replaces the nitrogen atom at the 7-position of guanine with a carbon atom, resulting in altered hydrogen bonding properties and stability. This modification enhances its resistance to degradation by nucleases, making it valuable in the design of oligonucleotides for therapeutic and diagnostic applications. 7-Deaza-ddG can participate in base pairing, allowing it to be incorporated into DNA strands during synthesis. Its unique properties can influence the binding affinity and specificity of nucleic acid interactions, making it a useful tool in studies involving gene expression, RNA interference, and antisense oligonucleotide design. Additionally, the compound is characterized by its solubility in aqueous solutions, which facilitates its use in various biochemical assays and experiments. Overall, 7-Deaza-ddG serves as an important building block in the development of nucleic acid-based technologies.

Formula: C₁₁H₁₄N₄O₃

Synonyms:

• 7-Deaza-ddG
• 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-amino-1,7-dihydro-7-[(2R,5S)-tetrahydro-5-(hydroxymethyl)-2-furanyl]- (9CI)
• 2',3'-Dideoxy-7-Deazaguanosine
• 2-Amino-7-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

2-Amino-7-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

CAS: 111869-49-9

2-Amino-7-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Purity: 97%

Molecular weight: 250.26g/mol

Ref: 54-OR1056285

7-Deaza-2',3'-dideoxyguanosine

CAS: 111869-49-9

7-Deaza-2',3'-dideoxyguanosine is a nucleoside analogue that is silylated on the 2' and 3' hydroxyl groups. It is also substituted with a deoxygenated 7-deaza-2',3'-dideoxyribose moiety. The substitution of the ribose sugar with deoxygenated 7-deaza-2',3'-dideoxyribose prevents the formation of hydrogen bonds between the sugar and phosphate backbones, which inhibits the enzyme ribonucleotide reductase from catalyzing the conversion of ribonucleotides to deoxynucleotides. This in turn blocks DNA synthesis, leading to cell death.br>
7-Deaza-2',3'-dideoxyguanosine has been shown to be effective against Mycobacterium tuberculosis and Mycobacterium avium complex.

Formula: C₁₁H₁₄N₄O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 250.26 g/mol

Ref: 3D-ND06191

7-Deaza-2',3'-dideoxyguanosine

CAS: 111869-49-9

7-Deaza-2',3'-dideoxyguanosine (7-Deaza-ddG) is a 2′,3′-dideoxynucleoside 5′-triphosphate that inhibits HIV-1 reverse transcriptase with a Ki of 25 nM [1].

Formula: C₁₁H₁₄N₄O₃

Color and Shape: Solid

Molecular weight: 250.25

Ref: TM-T60371