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CAS 111902-57-9

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Temocapril

Description:
Temocapril is an angiotensin-converting enzyme (ACE) inhibitor primarily used in the treatment of hypertension and heart failure. It functions by inhibiting the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced blood pressure. The chemical structure of Temocapril includes a carboxyl group, which is essential for its activity, and it is characterized by its ability to form a stable complex with the ACE enzyme. This compound is typically administered orally and is known for its relatively long half-life, allowing for once-daily dosing. Temocapril is also noted for its favorable side effect profile compared to other ACE inhibitors, although it may still cause common adverse effects such as cough, hyperkalemia, and hypotension. As with other medications in its class, it is contraindicated in pregnancy due to potential teratogenic effects. Overall, Temocapril represents a valuable therapeutic option in managing cardiovascular conditions, contributing to improved patient outcomes in hypertension and related disorders.
Formula:C23H28N2O5S2
InChI:InChI=1S/C23H28N2O5S2/c1-2-30-23(29)17(11-10-16-7-4-3-5-8-16)24-18-15-32-20(19-9-6-12-31-19)13-25(22(18)28)14-21(26)27/h3-9,12,17-18,20,24H,2,10-11,13-15H2,1H3,(H,26,27)/t17-,18-,20-/m0/s1
InChI key:InChIKey=FIQOFIRCTOWDOW-BJLQDIEVSA-N
SMILES:C(C(O)=O)N1C[C@H](SC[C@H](N[C@@H](CCC2=CC=CC=C2)C(OCC)=O)C1=O)C3=CC=CS3
Synonyms:
  • (+)-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid
  • (2S)-2-{[(2S)-4-(carboxymethyl)-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-6-yl]amino}-4-phenylbutanoic acid
  • (2S)-2-{[(2S,6R)-4-(carboxymethyl)-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-6-yl]amino}-4-phenylbutanoic acid
  • (2S,6R)-6-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic acid
  • (2S,6R)-6-[[(1S)-1-Carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid
  • 1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, (2S,6R)-
  • 1,4-Thiazepine-4(5H)-acetic acid, 6-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, [2S-[2α,6β(R*)]]-
  • 2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-Phenyl-Propyl]Amino]-5-Oxo-2-Thiophen-2-Yl-1,4-Thiazepan-4-Yl]Acetic Acid
  • Rs-5139
  • Temocapril
  • See more synonyms
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