CAS 111911-87-6

Rebamipide

Description:

Rebamipide is a synthetic compound primarily used in the treatment of gastric mucosal injuries and disorders, such as gastritis and peptic ulcers. It is classified as a gastroprotective agent and is known for its ability to enhance mucosal defense mechanisms. Chemically, Rebamipide is characterized by its unique structure, which includes a 2-aminobenzothiazole moiety, contributing to its pharmacological properties. The substance exhibits anti-inflammatory effects and promotes the synthesis of mucin, a key component of the gastric mucosal barrier. Additionally, Rebamipide has antioxidant properties, helping to mitigate oxidative stress in gastric tissues. It is typically administered orally and is well-absorbed, with a favorable safety profile. The compound's mechanism of action involves the stimulation of prostaglandin synthesis and the enhancement of epithelial cell proliferation, which aids in the healing of gastric mucosa. Overall, Rebamipide plays a significant role in gastroenterology, particularly in protecting and healing the gastric lining.

Formula: C₁₉H₁₅ClN₂O₄

InChI: InChI=1S/C19H15ClN2O4/c20-13-7-5-11(6-8-13)18(24)22-16(19(25)26)9-12-10-17(23)21-15-4-2-1-3-14(12)15/h1-8,10,16H,9H2,(H,21,23)(H,22,24)(H,25,26)

InChI key: InChIKey=ALLWOAVDORUJLA-UHFFFAOYSA-N

SMILES: C(C(NC(=O)C1=CC=C(Cl)C=C1)C(O)=O)C=2C=3C(NC(=O)C2)=CC=CC3

Synonyms:

• OPC 12759
• Proamipide
• 4-Quinolinepropanoic acid, α-[(4-chlorobenzoyl)amino]-1,2-dihydro-2-oxo-
• Rebamipide
• α-[(4-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic acid

Rebamipide

CAS: 111911-87-6

Rebamipide is a peptide that activates the receptor GPR18. It has been shown to inhibit ion channels and ligand-gated ion channels. This drug also has an affinity for the antibody Fc gamma RIIIa binding site, which may be due to its ability to inhibit the activity of T lymphocytes. Rebamipide binds to cell membrane receptors and inhibits the release of proinflammatory cytokines such as IL-6, IL-8, and TNF-α.

Formula: C₁₉H₁₅ClN₂O₄

Purity: Min. 95%

Molecular weight: 370.8 g/mol

Ref: 3D-LEA91187