CAS 111930-01-9

4-HYDROXY KETOROLAC

Description:

4-Hydroxy ketorolac is a non-steroidal anti-inflammatory drug (NSAID) that is primarily used for its analgesic properties. It is a derivative of ketorolac, which is known for its effectiveness in managing moderate to severe pain. The chemical structure of 4-hydroxy ketorolac includes a hydroxyl group, which contributes to its pharmacological activity. This compound exhibits anti-inflammatory effects by inhibiting the cyclooxygenase (COX) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of inflammation and pain. It is typically administered in various formulations, including oral and injectable forms. The substance is characterized by its relatively high solubility in organic solvents and moderate solubility in water, which influences its bioavailability and therapeutic efficacy. Safety profiles indicate potential side effects similar to other NSAIDs, such as gastrointestinal discomfort and renal effects, necessitating careful consideration in patients with pre-existing conditions. Overall, 4-hydroxy ketorolac represents a significant option in pain management, particularly in postoperative settings.

Formula: C₁₅H₁₃NO₄

InChI: InChI=1/C15H13NO4/c17-10-3-1-9(2-4-10)14(18)13-6-5-12-11(15(19)20)7-8-16(12)13/h1-6,11,17H,7-8H2,(H,19,20)

SMILES: c1cc(ccc1C(=O)c1ccc2C(CCn12)C(=O)O)O

Synonyms:

• 4-Hydroxyketorolac
• p-Hydroxyketorolac
• 1H-Pyrrolizine-1-carboxylic acid, 2,3-dihydro-5-(4-hydroxybenzoyl)-, (+-)-
• 5-[(4-hydroxyphenyl)carbonyl]-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
• Ketorolac 4-Hydroxy Metabolite
• 4-HYDROXY KETOROLAC
• Ketorolac tromethamine intermediate 6 Impurity 16
• Ketorolac Impurity 46

4-Hydroxy Ketorolac

CAS: 111930-01-9

Formula: C₁₅H₁₃NO₄

Color and Shape: Brown Solid

Molecular weight: 271.27

Ref: 4Z-K-031

4-Hydroxy Ketorolac

Controlled Product

CAS: 111930-01-9

Formula: C₁₅H₁₃NO₄

Color and Shape: Neat

Molecular weight: 271.268

Ref: TR-H943650

4-Hydroxy ketorolac

CAS: 111930-01-9

4-Hydroxy ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the class of phenylacetic acid derivatives. Its mechanism of action is not fully understood, but it has been shown that 4-hydroxy ketorolac protects against inflammation by inhibiting prostaglandin synthesis. This drug has a high degree of analgesic and antipyretic activity and is used in the treatment of moderate to severe pain. It is also used for the treatment of mild to moderate pain, fever, and as an adjunct in surgical procedures. 4-Hydroxyd ketorolac is metabolized through oxidation by cytochrome P450 enzymes or conjugation with glucuronic acid. Metabolites may be identified using analytical methods such as HPLC.
4-hydroxy ketorolac is an impurity standard for HPLC analysis and can be used as a reference substance for pharmacopoeia purposes. This drug product

Formula: C₁₅H₁₃NO₄

Purity: Min. 95%

Molecular weight: 271.27 g/mol

Ref: 3D-LEA93001

4-Hydroxy Ketorolac

CAS: 111930-01-9

Formula: C₁₅H₁₃NO₄

Molecular weight: 271.27

Ref: ST-EA-CP-K4030