CAS 111974-69-7

Quetiapine

Description:

Quetiapine is an atypical antipsychotic medication primarily used to treat schizophrenia, bipolar disorder, and major depressive disorder. It functions by modulating various neurotransmitter systems in the brain, particularly by antagonizing dopamine D2 and serotonin 5-HT2A receptors, which helps to alleviate symptoms of psychosis and mood disorders. Quetiapine is characterized by its relatively low affinity for muscarinic receptors, which contributes to its favorable side effect profile compared to older antipsychotics. The substance is typically administered in tablet form and is known for its sedative properties, making it useful in managing acute agitation. Quetiapine has a half-life that allows for once or twice daily dosing, and it undergoes extensive hepatic metabolism, primarily via the cytochrome P450 system. Common side effects may include drowsiness, dizziness, and metabolic changes, such as weight gain. As with any medication, it is essential for patients to be monitored for potential adverse effects and to discuss any concerns with their healthcare provider.

Formula: C₂₁H₂₅N₃O₂S

InChI: InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2

InChI key: InChIKey=URKOMYMAXPYINW-UHFFFAOYSA-N

SMILES: C(COCCO)N1CCN(C=2C=3C(SC=4C(N2)=CC=CC4)=CC=CC3)CC1

Synonyms:

• 11-[4-[2-(2-Hydroxyethoxy)Ethyl]-1-Piperazinyl]Dibenzo[B,F][1,4]Thiazepine
• 2-(2-(4-Dibenzo(b,f)(1,4)thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol
• 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethoxy]ethanol (2E)-but-2-enedioate (2:1) (salt)
• 2-{2-4-(Dibenzob,F1,4Thiazepin-11-Yl)Piperazin-1-Ylethoxy}Ethanol
• 2-{2-[4-(Dibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinyl]ethoxy}ethanol
• 2-{2-[4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl]ethoxy}ethanol
• 2-{[2-(4-Dibenzo[B,F][1,4]Thiazepin-11-Ylpiperazin-1-Yl)Ethyl]Oxy}Ethanol
• Dibenzo[b,f][1,4]thiazepine, ethanol deriv.
• Ethanol, 2-2-(4-Dibenzob,F1,4Thiazepin-11-Yl-1-Piperazinyl)Ethoxy-
• Ethanol, 2-[2-(4-Dibenzo[B,F][1,4]Thiazepin-11-Yl-1-Piperazinyl)Ethoxy]-
• Ketipinor
• Seronia

Quetiapine Hemifumarate

CAS: 111974-69-7, 111974-72-2

Formula: C₂₁H₂₅N₃O₂SC₄H₄O₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 441.55

Ref: 3B-Q0092

2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol

CAS: 111974-69-7

Formula: C₂₁H₂₅N₃O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 383.5071

Ref: IN-DA003EQ0

Quetiapine

CAS: 111974-69-7

Quetiapine treats schizophrenia and bipolar I, targeting serotonin, dopamine, and adrenoreceptor subtypes, plus H1 histamine receptor.

Formula: C₂₁H₂₅N₃O₂S

Purity: 99.14% - 99.63%

Color and Shape: White To Off-White Crystalline Powder

Molecular weight: 383.51

Ref: TM-T0162

Quetiapine

CAS: 111974-69-7

Formula: C₂₁H₂₅N₃O₂S

Color and Shape: Pale Yellow Solid

Molecular weight: 383.51

Ref: 4Z-Q-0116

Quetiapine

CAS: 111974-69-7

Quetiapine

Purity: ≥98%

Molecular weight: 383.51g/mol

Ref: 54-BUP14494

Quetiapine

Controlled Product

CAS: 111974-69-7

Stability Very Very Hygroscopic
Applications Quetiapine is a dibenzothiazepine antipsychotic commonly used as monotherapy for patients with major depressive disorder and schizophrenia.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cutler, A., et al.: J. Clin. Psych., 70, 526 (2009); Kapur, S., et al.: Arch. Gen. Psych., 57, 553 (2000); Peuskens, J. & Link, C.: Acta. Psych. Scand., 96, 265 (1997)

Formula: C₂₁H₂₅N₃O₂S

Color and Shape: Off-White To Yellow

Molecular weight: 383.51

Ref: TR-Q509900

Quetiapine

Controlled Product

CAS: 111974-69-7

Quetiapine is a psychotropic drug that belongs to the class of atypical antipsychotics. It is used in the treatment of schizophrenia and bipolar disorder. Quetiapine has been shown to have a potent inhibitory effect on prolactin levels, which may be due to its ability to induce fumarate reductase and increase blood flow to the hypothalamus. Quetiapine also interacts with a number of other drugs and can lead to adverse reactions when taken with them. The clinical efficacy of quetiapine for schizophrenia was demonstrated by a double-blind, randomized, placebo-controlled trial involving over 400 patients. The therapeutic efficacy of quetiapine has also been demonstrated in treatment trials involving patients with acute mania associated with bipolar disorder and schizoaffective disorder.

Formula: C₂₁H₂₅N₃O₂S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 383.51 g/mol

Ref: 3D-FQ32483

Quetiapine

CAS: 111974-69-7

Formula: C₂₁H₂₅N₃O₂S

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 383.167

Ref: 10-F242500