CAS 111974-72-2

Quetiapine fumarate

Description:

Quetiapine fumarate is an atypical antipsychotic medication primarily used to treat schizophrenia, bipolar disorder, and major depressive disorder. It is a salt form of quetiapine, which is a dibenzothiazepine derivative. The compound exhibits a complex pharmacological profile, acting as an antagonist at various neurotransmitter receptors, including serotonin (5-HT2A) and dopamine (D2) receptors, which contributes to its therapeutic effects. Quetiapine fumarate is typically administered orally and is known for its relatively favorable side effect profile compared to older antipsychotics, although it can still cause sedation, weight gain, and metabolic changes. The substance is characterized by its solubility in water and organic solvents, which facilitates its formulation in various dosage forms. Its chemical structure includes a thienobenzodiazepine core, contributing to its pharmacological activity. As with any medication, careful monitoring is essential to manage potential side effects and ensure effective treatment outcomes.

Formula: C₂₁H₂₅N₃O₂SC₄H₄O₄

InChI: InChI=1S/C21H25N3O2S.C4H4O4/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21;5-3(6)1-2-4(7)8/h1-8,25H,9-16H2;1-2H,(H,5,6)(H,7,8)/b;2-1+

InChI key: InChIKey=VRHJBWUIWQOFLF-WLHGVMLRSA-N

SMILES: C(COCCO)N1CCN(C=2C=3C(SC=4C(N2)=CC=CC4)=CC=CC3)CC1.C(=C/C(O)=O)\C(O)=O

Synonyms:

• 2-[2-(4-Dibenzo[B,F][1,4]Thiazepin-11-Yl-1-Piperazinyl)Ethoxy]Ethanol Hemifumarate
• 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethoxy]ethanol (2E)-but-2-enedioate (salt)
• Dibenzo[b,f][1,4]thiazepine, ethanol deriv.
• Ethanol, 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-, (2E)-2-butenedioate (2:1)
• Ethanol, 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-, (2E)-2-butenedioate (2:1) (salt)
• Ethanol, 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-, (E)-2-butenedioate (2:1) (salt)
• Ici 204636
• Kwetaplex
• Loquen
• Quetiapine Fumarate Main Intermediates
• Quetiapine hemifumarate
• Quetinapine Fumarate
• Quetros
• Quitpin
• Seroquel
• Zd 5077

Quetiapine-[13C4] hemifumarate

CAS: 111974-72-2

Ref: BE-MC-7273

Quetiapine Hemifumarate in Methanol(as free base)

CAS: 111974-72-2

Methanol(as free base)

Ref: BE-MU-7194YM-1000

Quetiapine Hemifumarate in Methanol

CAS: 111974-72-2

Methanol

Ref: BE-MU-7194LM-10

Quetiapine hemifumarate

Controlled Product

CAS: 111974-72-2

Quetiapine hemifumarate is an antipsychotic drug that blocks receptors for dopamine, serotonin, and adrenergic neurotransmitters. It is used to treat schizophrenia and other disorders such as bipolar disorder. Quetiapine has been shown to be effective in clinical trials. The fumarate salt of quetiapine is the form of the drug that is used in these trials. Serum prolactin levels were found to be significantly lower in patients who received the fumarate salt than those who received a placebo. Quetiapine hemifumarate may potentiate the effects of other drugs by inducing their metabolism via CYP3A4 or CYP2D6 enzymes, which are also responsible for its own metabolism. This drug can interact with other drugs such as risperidone, olanzapine, and clozapine due to its atypical nature. Quetiapine hemifumarate has side effects

Formula: C₂₁H₂₅N₃O₂S•(C₄H₄O₄)₀

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 441.54 g/mol

Ref: 3D-ID57889

Quetiapine Fumarate RS

CAS: 111974-72-2

Color and Shape: White Solid Crystalline Powder

Ref: 2K-1047200021