CAS 112111-43-0

(-)-Modafinil

Description:

(-)-Modafinil, with the CAS number 112111-43-0, is a wakefulness-promoting agent primarily used to treat sleep disorders such as narcolepsy and obstructive sleep apnea. It is a chiral compound, meaning it exists in two enantiomeric forms; the (-)-enantiomer is the more pharmacologically active form. The substance is classified as a eugeroic, which enhances alertness and cognitive function without the stimulant effects typically associated with amphetamines. Chemically, (-)-Modafinil is a benzhydryl sulfinyl compound, featuring a sulfinyl group that contributes to its unique pharmacological profile. It has a relatively low potential for abuse compared to traditional stimulants, making it a preferred option in certain therapeutic contexts. The compound exhibits a favorable pharmacokinetic profile, with a long half-life and minimal side effects, although it can interact with various medications due to its effects on liver enzymes. Overall, (-)-Modafinil is recognized for its efficacy in promoting wakefulness and enhancing cognitive performance, making it a significant substance in both clinical and off-label use.

Formula: C₁₅H₁₅NO₂S

InChI: InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)/t19-/m1/s1

InChI key: InChIKey=YFGHCGITMMYXAQ-LJQANCHMSA-N

SMILES: C(S(CC(N)=O)=O)(C1=CC=CC=C1)C2=CC=CC=C2

Synonyms:

• (-)-Modafinil
• 2-[(Diphenylmethyl)Sulfinyl]Acetamide
• 2-[(R)-(Diphenylmethyl)sulfinyl]-acetamide
• Acetamide, 2-[(R)-(diphenylmethyl)sulfinyl]-
• Armodafinil
• Cep 10952
• Crl 40982
• Nuvigil

(R)-Modafinil

CAS: 112111-43-0

Formula: C₁₅H₁₅NO₂S

Color and Shape: White To Off-White Solid

Molecular weight: 273.35

Ref: 4Z-M-336

Armodafinil

CAS: 112111-43-0

Formula: C₁₅H₁₅NO₂S

Purity: ≥ 98.0%

Color and Shape: White to off-white powder or solid

Molecular weight: 273.35

Ref: 7W-GP7440

(R)-Modafinil

Controlled Product

CAS: 112111-43-0

Applications Used for treatment of excessive sleepiness, α1-adrenoceptor agonist.
References Saletu, B., et al.: Int. J. Clin. Pharmacol. Res., 9, 183 (1989), Chemelli, R.M., et al.: Cell, 98, 437 (1999), Purnell, M., et al.: J. Sleep Res., 11, 219 (2002), Dinges, D., et al.: Curr. Med. Res. Opin., 22, 159 (2006)

Formula: C₁₅H₁₅NO₂S

Color and Shape: Neat

Molecular weight: 273.35

Ref: TR-M482505

(R)-Modafinil

Controlled Product

CAS: 112111-43-0

Cognitive enhancer; anti-narcoleptic; dopamine reuptake transporter ligand

Formula: C₁₅H₁₅NO₂S

Purity: Min. 95%

Molecular weight: 273.35 g/mol

Ref: 3D-FM26031

Armodafinil CIV

Controlled Product

CAS: 112111-43-0

Other aromatic organo-sulfur compounds (excluding pesticides)

Formula: C₁₅H₁₅NO₂S

Color and Shape: White Off-White Powder

Molecular weight: 273.08235

Ref: 45-1042758