CAS 112111-47-4

(+)-Modafinil

Description:

(+)-Modafinil, with the CAS number 112111-47-4, is a wakefulness-promoting agent primarily used to treat conditions such as narcolepsy, obstructive sleep apnea, and shift work sleep disorder. It is a racemic compound, but the (+) enantiomer is the more pharmacologically active form. The substance is classified as a eugeroic, which means it enhances alertness and cognitive function without the stimulant effects commonly associated with traditional amphetamines. Chemically, it is a benzhydryl sulfinyl compound, and its structure features a sulfinyl group attached to a benzhydryl moiety. (+)-Modafinil exhibits a relatively low potential for abuse compared to other stimulants, making it a preferred option in clinical settings. Its mechanism of action is not fully understood but is believed to involve the modulation of neurotransmitters such as dopamine and norepinephrine. Additionally, it has a favorable pharmacokinetic profile, with a long half-life and minimal side effects, contributing to its popularity in both medical and off-label use for cognitive enhancement.

Formula: C₁₅H₁₅NO₂S

InChI: InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)/t19-/m0/s1

InChI key: InChIKey=YFGHCGITMMYXAQ-IBGZPJMESA-N

SMILES: C(S(CC(N)=O)=O)(C1=CC=CC=C1)C2=CC=CC=C2

Synonyms:

• (+)-Modafinil
• 2-[(S)-(Diphenylmethyl)sulfinyl]acetamide
• Acetamide, 2-[(S)-(diphenylmethyl)sulfinyl]-
• Crl 40983
• Nh 02D
• (S)-(+)-Modafinil

(S)-Modafinil

CAS: 112111-47-4

Formula: C₁₅H₁₅NO₂S

Color and Shape: White To Off-White Solid

Molecular weight: 273.35

Ref: 4Z-M-335

(S)-Modafinil

Controlled Product

CAS: 112111-47-4

Applications Used for treatment of excessive sleepiness, α1-adrenoceptor agonist.
References Saletu, B., et al.: Int. J. Clin. Pharmacol. Res., 9, 183 (1989), Chemelli, R.M., et al.: Cell, 98, 437 (1999), Purnell, M., et al.: J. Sleep Res., 11, 219 (2002), Dinges, D., et al.: Curr. Med. Res. Opin., 22, 159 (2006)

Formula: C₁₅H₁₅NO₂S

Color and Shape: Neat

Molecular weight: 273.35

Ref: TR-M482506

(S)-Modafinil

CAS: 112111-47-4

Formula: C₁₅H₁₅NO₂S

Molecular weight: 273.35

Ref: ST-EA-CP-A23002

Modafinil S-enantiomer CIV ((S)-2-(Benzhydrylsulfinyl)acetamide)

Controlled Product

CAS: 112111-47-4

Other aromatic organo-sulfur compounds (excluding pesticides)

Formula: C₁₅H₁₅NO₂S

Color and Shape: White Off-White Solid

Molecular weight: 273.08235

Ref: 45-1445415

(S)-Modafinil

Controlled Product

CAS: 112111-47-4

Modafinil is a racemic mixture of the enantiomers, d-modafinil and l-modafinil. It is a wakefulness promoting agent that has been approved for the treatment of narcolepsy in the US, EU, Canada, and Australia. Modafinil binds to the dopamine transporter and blocks its activity, which increases extracellular dopamine levels. It also inhibits the reuptake of serotonin and norepinephrine from their presynaptic terminals, resulting in increased extracellular levels of these neurotransmitters. Modafinil may be useful for treating other disorders such as cocaine dependence and Parkinson's disease.

Formula: C₁₅H₁₅NO₂S

Purity: Min. 98 Area-%

Color and Shape: White To Off-White Solid

Molecular weight: 273.35 g/mol

Ref: 3D-FM26032