CAS 112233-74-6

N2-ACETYL-O6-(DIPHENYLCARBAMOYL)GUANINE

Description:

N2-Acetyl-O6-(diphenylcarbamoyl)guanine, identified by the CAS number 112233-74-6, is a modified guanine derivative that features an acetyl group at the N2 position and a diphenylcarbamoyl moiety at the O6 position. This compound is characterized by its potential applications in biochemistry and medicinal chemistry, particularly in the study of nucleic acid interactions and as a potential therapeutic agent. The presence of the acetyl group may enhance lipophilicity, influencing its biological activity and solubility. The diphenylcarbamoyl group can provide steric bulk, which may affect the compound's binding affinity to biological targets, such as enzymes or receptors. Additionally, the structural modifications can impact the compound's stability and reactivity, making it a subject of interest in drug design and development. Overall, N2-acetyl-O6-(diphenylcarbamoyl)guanine exemplifies the intricate relationship between chemical structure and biological function, highlighting the importance of such derivatives in pharmaceutical research.

Formula: C₂₀H₁₆N₆O₃

2-Acetamido-7H-purin-6-yl diphenylcarbamate

CAS: 112233-74-6

Formula: C₂₀H₁₆N₆O₃

Purity: 96%

Molecular weight: 388.3794

Ref: IN-DA01DG3K

N2-Acetyl-O6-diphenylcarbamoylguanine

CAS: 112233-74-6

N2-Acetyl-O6-diphenylcarbamoylguanine is an amide nucleoside that is a potent antiviral agent. It inhibits the synthesis of viral DNA by inhibiting viral DNA polymerase. N2-Acetyl-O6-diphenylcarbamoylguanine also has reactive functional groups that can react with other molecules, such as human serum albumin, to form conjugates that are more stable and can be used for long periods of time. This nucleoside is synthesized by reacting uridine with chloroacetamide and then reacting the resulting product with diphenylcarbamoyl chloride in the presence of triethylamine. The ring opening reaction leads to the formation of a glycosidic linkage between N2-Acetyl-O6-diphenylcarbamoylguanine and the sugar molecule. This nucleoside has been shown to

Formula: C₂₀H₁₆N₆O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 388.38 g/mol

Ref: 3D-FA08314

N2-Acetyl-O6-diphenylcarbamoylguanine-13C2,15N

Controlled Product

CAS: 112233-74-6

Applications N2-Acetyl-O6-diphenylcarbamoylguanine-13C2,15N is an intermediate in the synthesis of 8-Aminoguanosine-13C2,15N (A609877). 8-Aminoguanosine-13C2,15N is an isotopic labelled compound of 8-Aminoguanosine (A609875), which is a potent inhibitor of purine nucleoside phosphorylase.
References Kazmers, I.S., et al.: Science, 214, 1137 (1981); Chern, J-W., et al.: J. Med. Chem., 36, 1024 (1993)

Formula: C₂C₁₈H₁₆₁₅NN₅O₃

Color and Shape: Neat

Molecular weight: 391.358

Ref: TR-A173842

N2-Acetyl-O6-diphenylcarbamoylguanine

Controlled Product

CAS: 112233-74-6

Applications N2-Acetyl-O6-diphenylcarbamoylguanine is a reactant in the synthesis of 1',2'-oxetane-nucleosides bearing 2'-C-Me substituents with anti-HCV activity.
References Komsta, Z., et. al.: Tetrahedron Lett., 55, 6216 (2014)

Formula: C₂₀H₁₆N₆O₃

Color and Shape: Neat

Molecular weight: 388.38

Ref: TR-A173840

2-Acetamido-9H-purin-6-yl diphenylcarbamate

CAS: 112233-74-6

Formula: C₂₀H₁₆N₆O₃

Molecular weight: 388.38

Ref: ST-EA-CP-A8085