CAS 1123837-84-2

N-[3-Fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N′-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

Description:

N-[3-Fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N′-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide, with CAS number 1123837-84-2, is a complex organic compound characterized by its multi-functional structure. It features a cyclopropanedicarboxamide core, which is notable for its potential biological activity. The presence of fluorine atoms in the molecule enhances its lipophilicity and may influence its pharmacokinetic properties. The compound also contains various aromatic and heterocyclic moieties, contributing to its potential interactions with biological targets. Its methoxyethyl and amino groups suggest possible solubility in organic solvents and potential for hydrogen bonding, which can affect its reactivity and stability. This compound is likely to be of interest in medicinal chemistry, particularly in the development of pharmaceuticals, due to its intricate structure that may confer specific biological activities. However, detailed studies would be necessary to fully elucidate its properties and potential applications.

Formula: C₃₃H₂₉F₂N₅O₄S

InChI: InChI=1S/C33H29F2N5O4S/c1-43-15-14-36-18-20-2-8-25(38-19-20)29-17-26-30(45-29)28(10-13-37-26)44-27-9-7-23(16-24(27)35)40-32(42)33(11-12-33)31(41)39-22-5-3-21(34)4-6-22/h2-10,13,16-17,19,36H,11-12,14-15,18H2,1H3,(H,39,41)(H,40,42)

InChI key: InChIKey=WLAVZAAODLTUSW-UHFFFAOYSA-N

SMILES: C(NC1=CC(F)=C(OC2=C3C(C=C(S3)C4=CC=C(CNCCOC)C=N4)=NC=C2)C=C1)(=O)C5(C(NC6=CC=C(F)C=C6)=O)CC5

Synonyms:

• MGCD 516
• N-[3-Fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N′-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
• N-(3-fluoro-4-{[2-(5-{[(2-methoxyethyl)amino]methyl}pyridin-2-yl)thieno[3,2-b]pyridin-7-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
• 1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N′-(4-fluorophenyl)-
• Sitravatinib

Sitravatinib

CAS: 1123837-84-2

Formula: C₃₃H₂₉F₂N₅O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 629.6763

Ref: IN-DA008TPJ

Sitravatinib

CAS: 1123837-84-2

Sitravatinib

Purity: ≥98%

Molecular weight: 629.68g/mol

Ref: 54-BUP15394

Sitravatinib

CAS: 1123837-84-2

Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and

Formula: C₃₃H₂₉F₂N₅O₄S

Purity: 98.9% - 99.85%

Color and Shape: Solid

Molecular weight: 629.68

Ref: TM-T4349

Sitravatinib

CAS: 1123837-84-2

Inhibits multiple receptor tyrosine kinases (RTKs), including c-Kit, PDGFRβ, PDGFRα, c-Met, and Axl. Sitravatinib inhibits proliferation of sarcoma cells and reduced tumor growth in vivo. Promotes immune response in tumor microenvironment and enhances sensitivity to immune checkpoint inhibitors. This compound is undergoing several clinical trials as a potential anti-cancer therapeutic agent.

Formula: C₃₃H₂₉F₂N₅O₄S

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 629.68 g/mol

Ref: 3D-BS166446

MGCD 516

Controlled Product

CAS: 1123837-84-2

Formula: C₃₃H₂₉F₂N₅O₄S

Color and Shape: Neat

Molecular weight: 629.676

Ref: TR-M340970