CAS 112501-53-8

1-[5-(O-DIMETHOXYTRITYL)-2-DEOXY-BETA-D-THREO-PENTOFURANOSYL]THYMINE

Description:

1-[5-(O-Dimethoxytrityl)-2-deoxy-beta-D-threo-pentofuranosyl]thymine is a modified nucleoside that features a thymine base linked to a sugar moiety, specifically a 2-deoxy-beta-D-threo-pentofuranose. The presence of the dimethoxytrityl (DMT) protecting group enhances its stability and solubility, making it suitable for various biochemical applications, particularly in the synthesis of oligonucleotides. This compound is characterized by its ability to participate in hydrogen bonding due to the thymine base, which is crucial for base pairing in nucleic acid structures. The modification of the sugar component contributes to its unique properties, influencing its reactivity and interaction with other biomolecules. Additionally, the DMT group can be selectively removed under specific conditions, allowing for further functionalization or incorporation into larger nucleic acid constructs. Overall, this compound is significant in the field of nucleic acid chemistry and molecular biology, particularly in the development of therapeutic agents and diagnostic tools.

Formula: C₃₁H₃₂N₂O₇

Synonyms:

• 2,4(1H,3H)-Pyrimidinedione, 1-[5-O-[Bis(4-Methoxyphenyl)Phenylmethyl]-2-Deoxy-Beta-D-Threo-Pentofuranosyl]-5-Methyl-
• 1-[5-O-(4,4'-Dimethoxytrityl)-2-Deoxy-Beta-D-Threo-Pentofuranosyl]Thymine
• DMTr-lyxothymidine
• 1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy--D-threo-pentofuranosyl]-5-methyl-2,4(1H,3H)pyrimidinedione
• 5'-O-(4,4'-Dimethoxytrityl)-3'--hydroxythymidine
• 1-(5-O-(4,4'-dimethoxytrityl)-2-deoxy-β-D-lyxofuranosyl)thymine
• 2,4(1H,3H)-Pyrimidinedione,1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D- threo-pentofuranosyl]-5-methyl-
• 1-[5-O-(4,4'-Dimethoxytrityl)-2-deoxy-β-D-
• threo-pentofuranosyl]-thymine

1-(2''-Deoxy-5''-O-DMT-b-D-lyxofuranosyl)thymine

CAS: 112501-53-8

Ref: 7W-GN2928

1-(2'-Deoxy-5'-O-DMT-b-D-lyxofuranosyl)thymine

CAS: 112501-53-8

1-(2'-Deoxy-5'-O-DMT-b-D-lyxofuranosyl)thymine is a nucleoside that can be used as a reagent in the synthesis of oligodeoxynucleotides. It has been shown to bind to DNA, and it is phosphoramidite monomer for solid phase synthesis of oligodeoxynucleotides. It is also a nonamer, octamer, and dinucleoside. 1-(2'-Deoxy-5'-O-DMT-b-D-lyxofuranosyl)thymine binds to the receptor protein and has been shown to have efficiencies as high as 45%.

Formula: C₃₁H₃₂N₂O₇

Purity: Min. 95%

Molecular weight: 544.6 g/mol

Ref: 3D-ND10367