CAS 112559-91-8

HYDROXY ITRACONAZOLE

Description:

Hydroxy itraconazole is a derivative of itraconazole, an antifungal agent commonly used to treat various fungal infections. It is characterized by its ability to inhibit the synthesis of ergosterol, a vital component of fungal cell membranes, thereby disrupting fungal growth and replication. Hydroxy itraconazole exhibits a broad spectrum of antifungal activity, particularly against species of Candida and Aspergillus. The compound is typically administered orally and is known for its improved solubility and bioavailability compared to its parent compound. Its pharmacokinetics involve extensive metabolism in the liver, leading to the formation of active metabolites. Hydroxy itraconazole is also noted for its potential interactions with other medications due to its effects on cytochrome P450 enzymes. In clinical settings, it is often used in cases where other antifungal treatments have failed or are not suitable. Safety profiles indicate that it may cause side effects, including gastrointestinal disturbances and liver enzyme elevations, necessitating monitoring during treatment. Overall, hydroxy itraconazole represents an important option in antifungal therapy, particularly for resistant infections.

Formula: C₃₅H₃₈Cl₂N₈O₅

InChI: InChI=1/C35H38Cl2N8O5/c1-24(25(2)46)45-34(47)44(23-40-45)29-6-4-27(5-7-29)41-13-15-42(16-14-41)28-8-10-30(11-9-28)48-18-31-19-49-35(50-31,20-43-22-38-21-39-43)32-12-3-26(36)17-33(32)37/h3-12,17,21-25,31,46H,13-16,18-20H2,1-2H3/t24?,25?,31-,35-/m0/s1

SMILES: CC(C(C)O)n1c(=O)n(cn1)c1ccc(cc1)N1CCN(CC1)c1ccc(cc1)OC[C@H]1CO[C@](Cn2cncn2)(c2ccc(cc2Cl)Cl)O1

Synonyms:

• 3H-1,2,4-Triazol-3-one, 4-4-4-4-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenyl-1-piperazinylphenyl-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-
• 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-3H-1,2,4-triazol-3-one
• R 63373
• 4-{4-[4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2-(3-hydroxybutan-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one
• 4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2-(2-hydroxy-1-methylpropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

HYDROXY ITRACONAZOLE

CAS: 112559-91-8

Formula: C₃₅H₃₈Cl₂N₈O₅

Purity: 99.74%

Color and Shape: Solid

Molecular weight: 721.6328

Ref: IN-DA007SXV

Hydroxy Itraconazole

CAS: 112559-91-8

Hydroxy Itraconazole

Purity: ≥98%

Molecular weight: 721.63g/mol

Ref: 54-BUP21156

Hydroxy Itraconazole

Controlled Product

CAS: 112559-91-8

Applications A metabolite of Itraconazole, an orally active antimycotic structurally related to Ketoconazole. It is a COVID19-related research product.
References Saag, M., et al.: Antimicrob. Agents Chemother., 32, 1 (1988), Haria, M., et al.: Drugs, 51, 585 (1996), Kousoulos, C., et al.: Anal. Bioanal. Chem., 384,199 (2006),

Formula: C₃₅H₄₀Cl₂N₈O₄

Color and Shape: White

Molecular weight: 707.65

Ref: TR-H943600

Hydroxy Itraconazole

CAS: 112559-91-8

Hydroxy Itraconazole (R63373) is a triazole compound with antifungal activity for the study of malignant tumors.

Formula: C₃₅H₃₈Cl₂N₈O₅

Purity: 99.59% - >99.99%

Color and Shape: Solid

Molecular weight: 721.63

Ref: TM-TQ0224

Hydroxy itraconazole

CAS: 112559-91-8

Hydroxyitraconazole is an antifungal drug that inhibits the synthesis of ergosterol, a component of fungal cell membranes. It has been shown to be effective against a number of human pathogens, including Aspergillus fumigatus and Candida albicans. Hydroxyitraconazole has a broad spectrum of activity against a range of microbial organisms and is active against Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus. The pharmacokinetic properties of hydroxyitraconazole have been studied in humans with normal renal function. A pharmacokinetic study was conducted to determine the effects on serum cortisol concentrations after administration of hydroxyitraconazole. This drug is not metabolized by cytochrome P450 enzymes and it does not induce or inhibit other drug metabolism pathways. Hydroxyitraconazole also has no significant interaction with other drugs or food products

Formula: C₃₅H₃₈Cl₂N₈O₅

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 721.63 g/mol

Ref: 3D-FH24024