CAS 112560-33-5

KETO ITRACONAZOLE

Description:

Keto itraconazole, identified by its CAS number 112560-33-5, is a triazole antifungal agent that is a derivative of itraconazole. It is primarily used in the treatment of various fungal infections, particularly those caused by dermatophytes and certain systemic mycoses. The compound exhibits a broad spectrum of antifungal activity by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting their integrity and function. Keto itraconazole is characterized by its lipophilic nature, which enhances its absorption and distribution in the body. It is typically administered orally and has a relatively long half-life, allowing for once-daily dosing in some cases. The substance is also known for its potential interactions with other medications due to its effects on cytochrome P450 enzymes. As with many antifungal agents, monitoring for side effects, including hepatotoxicity and gastrointestinal disturbances, is essential during treatment. Overall, keto itraconazole represents an important therapeutic option in the management of fungal infections.

Formula: C₃₅H₃₆Cl₂N₈O₅

InChI: InChI=1/C35H36Cl2N8O5/c1-24(25(2)46)45-34(47)44(23-40-45)29-6-4-27(5-7-29)41-13-15-42(16-14-41)28-8-10-30(11-9-28)48-18-31-19-49-35(50-31,20-43-22-38-21-39-43)32-12-3-26(36)17-33(32)37/h3-12,17,21-24,31H,13-16,18-20H2,1-2H3/t24?,31-,35-/m0/s1

SMILES: CC(C(=O)C)n1c(=O)n(cn1)c1ccc(cc1)N1CCN(CC1)c1ccc(cc1)OC[C@H]1CO[C@](Cn2cncn2)(c2ccc(cc2Cl)Cl)O1

Synonyms:

• keto-ITZ
• rel-4-[4-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methyl-2-oxopropyl)-3H-1,2,4-triazol-3-one

Keto-itraconazole

CAS: 112560-33-5

Keto-itraconazole is a metabolite of Itraconazole.

Formula: C₃₅H₃₆Cl₂N₈O₅

Color and Shape: Solid

Molecular weight: 719.62

Ref: TM-T32389

Keto Itraconazole

CAS: 112560-33-5

Formula: C₃₅H₃₆Cl₂N₈O₅

Color and Shape: White To Off-White Solid

Molecular weight: 719.62

Ref: 4Z-I-035

Keto Itraconazole

Controlled Product

CAS: 112560-33-5

Formula: C₃₅H₃₆Cl₂N₈O₅

Color and Shape: Neat

Molecular weight: 719.62

Ref: TR-K195000

Keto itraconazole

CAS: 112560-33-5

Keto itraconazole is an interaction-enhancing agent that is used to improve the chromatographic resolution and detection of the target analytes. It has been used in validation studies for bioanalytical methods, pharmacokinetics studies, and regression analysis. Keto itraconazole enhances the sensitivity of HPLC by increasing the linear range of a detector at a flow rate of 1 mL/min. The enhancement is due to a reduction in the back-pressure on the column, which allows for increased elution of analytes.

Formula: C₃₅H₃₆Cl₂N₈O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 719.62 g/mol

Ref: 3D-FK24776

Keto Itraconazole-d8

Controlled Product

CAS: 112560-33-5

Formula: C₃₅D₈H₂₈Cl₂N₈O₅

Color and Shape: Neat

Molecular weight: 727.666

Ref: TR-K195002

Keto Itraconazole

CAS: 112560-33-5

Formula: C₃₅H₃₆Cl₂N₈O₅

Molecular weight: 719.62

Ref: ST-EA-CP-I3026