CAS 112573-72-5

Dexecadotril

Description:

Dexecadotril, with the CAS number 112573-72-5, is a synthetic compound primarily known for its role as an enkephalinase inhibitor. It is characterized by its ability to modulate the activity of endogenous opioid peptides, which can influence pain perception and other physiological processes. Dexecadotril is often studied for its potential therapeutic applications, particularly in the context of pain management and gastrointestinal disorders. The compound exhibits a relatively low molecular weight and is soluble in various organic solvents, which facilitates its use in pharmaceutical formulations. Its mechanism of action involves the inhibition of the enzyme that breaks down enkephalins, thereby increasing their availability and enhancing their effects. Additionally, Dexecadotril has been investigated for its safety profile and pharmacokinetics, making it a subject of interest in drug development. Overall, its unique properties and biological activity position Dexecadotril as a noteworthy candidate in the field of medicinal chemistry.

Formula: C₂₁H₂₃NO₄S

InChI: InChI=1/C21H23NO4S/c1-16(23)27-15-19(12-17-8-4-2-5-9-17)21(25)22-13-20(24)26-14-18-10-6-3-7-11-18/h2-11,19H,12-15H2,1H3,(H,22,25)/t19-/m0/s1

SMILES: CC(=O)SC[C@H](Cc1ccccc1)C(=NCC(=O)OCc1ccccc1)O

Synonyms:

• Dexecadotril [INN]
• (+)-N-((R)-alpha-(Mercaptomethyl)hydrocinnamoyl)glycine, benzyl ester, acetate (ester)
• (R)-Acetorphan
• (R)-N-(2-((Acetylthio)methyl)-1-oxo-3-phenylpropyl)glycine phenylmethyl ester
• N-(2-Acetylthiomethyl-1-oxo-3-phenylpropyl)glycine-R(+)-benzyl ester
• Retorphan
• Unii-5Ofi9D9892
• Glycine, N-(2-((acetylthio)methyl)-1-oxo-3-phenylpropyl)-, phenylmethyl ester, (R)-
• benzyl N-[(2R)-3-(acetylsulfanyl)-2-benzylpropanoyl]glycinate
• Glycine, N-[(2R)-2-[(acetylthio)methyl]-1-oxo-3-phenylpropyl]-, phenylmethyl ester
• Surotomycin
• benzyl 2-[[(2R)-2-(acetylsulfanylmethyl)-3-phenylpropanoyl]amino]acetate
• N-[(R)-2-Benzyl-3-(acetylthio)propionyl]glycine benzyl ester
• Dexecadotril

Retorphan-d5

Controlled Product

CAS: 112573-72-5

Formula: C₂₁D₅H₁₈NO₄S

Color and Shape: Neat

Molecular weight: 390.507

Ref: TR-R278502

Retorphan

Controlled Product

CAS: 112573-72-5

Applications Retorphan is a powerful and selective inhibitors of neprilysin and is being developed as a therapeutic agent. Retorphan behave as the prodrug of the enantiomers of Thiorphan (T369500).
References Monteil, T., et al.: Mini. Rev. Med. Chem., 2, 209 (2002); Roques, B.P., et al.: Nature, 288, 286 (1980); Tiraboschi, G., et al.: Protein Engineering, 12, 2, 141 (1999)

Formula: C₂₁H₂₃NO₄S

Color and Shape: Neat

Molecular weight: 385.48

Ref: TR-R278500

Retorphan

CAS: 112573-72-5

Retorphan, a peptide inhibitor, is used as a research tool to study protein interactions and receptor signaling. It has been shown to be an activator of Ligand-gated ion channels, inhibiting the current in response to ligands such as acetylcholine and serotonin. Retorphan also inhibits the activity of Protein Kinase C. Retorphan is a high purity compound with a purity greater than 99%.

Formula: C₂₁H₂₃NO₄S

Purity: Min. 95%

Molecular weight: 385.5 g/mol

Ref: 3D-MEA57372

Dexecadotril

CAS: 112573-72-5

Dexecadotril is a powerful and selective neprilysin inhibitor. It behaves as a prodrug of the enantiomer of thiorphan.

Formula: C₂₁H₂₃NO₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 385.48

Ref: TM-T25316