CAS 1126432-68-5

Quetiapine Impurity (N,N-bis[(2-phenylthio)phenyl]-1,4-piperazinedicarboxamide)

Description:

Quetiapine Impurity, specifically N,N-bis[(2-phenylthio)phenyl]-1,4-piperazinedicarboxamide, is a chemical compound that serves as an impurity associated with the antipsychotic medication quetiapine. This compound features a piperazine core, which is a common structural motif in many pharmacologically active compounds. The presence of two phenylthio groups contributes to its unique chemical properties, potentially influencing its solubility and reactivity. The compound is characterized by its molecular structure, which includes multiple aromatic rings that can affect its interaction with biological targets. As an impurity, it may arise during the synthesis of quetiapine and could have implications for the drug's efficacy and safety profile. Understanding the characteristics of such impurities is crucial for quality control in pharmaceutical manufacturing, as they can impact the overall therapeutic outcomes and regulatory compliance. Analytical techniques such as chromatography and mass spectrometry are typically employed to identify and quantify such impurities in pharmaceutical formulations.

Formula: C₃₀H₂₈N₄O₂S₂

Synonyms:

• 1,4-Piperazinedicarboxamide, N1,N4-bis[2-(phenylthio)phenyl]-
• Quetiapine Impurity (N,N-bis[(2-phenylthio)phenyl]-1,4-piperazinedicarboxamide)
• N1,N4-Bis[2-(phenylthio)phenyl]-1,4-piperazinedicarboxamide

N1,N4-Bis[2-(phenylthio)phenyl]-1,4-piperazine-d8-dicarboxamide

Controlled Product

CAS: 1126432-68-5

Applications N1,N4-Bis[2-(phenylthio)phenyl]-1,4-piperazine-d8-dicarboxamide is the labeled analog of N1,N4-Bis[2-(phenylthio)phenyl]-1,4-piperazinedicarboxamide (B522635), an impurity of Quetiapine (Q510000), a benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties; used as an antipsychotic.
References Stolarczyk, E.U., et. al.: Pharm. Develp. Tech., 14, 27 (2009); Wetzel, H., et al.: Psychopharmacology, 119, 231 (1995)

Formula: C₃₀H₂₀D₈N₄O₂S₂

Color and Shape: Neat

Molecular weight: 410.452

Ref: TR-B522637

N1,N4-Bis[2-(phenylthio)phenyl]-1,4-piperazinedicarboxamide

Controlled Product

CAS: 1126432-68-5

Formula: C₃₀H₂₈N₄O₂S₂

Color and Shape: Neat

Molecular weight: 540.7

Ref: TR-B522635

Quetiapine Impurity 8

CAS: 1126432-68-5

Formula: C₃₀H₂₈N₄O₂S₂

Molecular weight: 540.70

Ref: ST-EA-CP-Q1048