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CAS 112668-56-1

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3′-Deoxy-3′,5-difluorouridine

Description:
3′-Deoxy-3′,5-difluorouridine is a synthetic nucleoside analog of uridine, characterized by the substitution of fluorine atoms at the 3′ and 5′ positions of the ribose sugar. This modification enhances its stability and alters its interaction with nucleic acid polymerases, making it a subject of interest in antiviral and anticancer research. The compound exhibits properties typical of nucleosides, including the ability to incorporate into RNA and DNA, potentially disrupting normal nucleic acid synthesis. Its fluorinated structure may also confer unique pharmacological properties, such as increased resistance to enzymatic degradation. 3′-Deoxy-3′,5-difluorouridine has been studied for its potential therapeutic applications, particularly in the treatment of viral infections and certain types of cancer, due to its ability to inhibit viral replication and tumor cell proliferation. As with many nucleoside analogs, its efficacy and safety profile are critical areas of ongoing research, and understanding its mechanism of action is essential for developing effective therapeutic strategies.
Formula:C9H10F2N2O5
InChI:InChI=1S/C9H10F2N2O5/c10-3-1-13(9(17)12-7(3)16)8-6(15)5(11)4(2-14)18-8/h1,4-6,8,14-15H,2H2,(H,12,16,17)/t4-,5-,6-,8-/m1/s1
InChI key:InChIKey=GJXRADCYCFGMRR-UAKXSSHOSA-N
SMILES:O[C@H]1[C@@H](O[C@H](CO)[C@H]1F)N2C(=O)NC(=O)C(F)=C2
Synonyms:
  • Uridine, 3′-deoxy-3′,5-difluoro-
  • 3′-Deoxy-3′,5-difluorouridine
  • 3’-Deoxy-3’-fluoro-5-fluorouridine
  • 3'-Deoxy-3'-fluoro-5-fluorouridine
  • Uridine, 3'-deoxy-3',5-difluoro-
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