CAS 1127226-56-5

Tiotropium-d3 Bromide

Description:

Tiotropium-d3 bromide is a labeled derivative of tiotropium, a long-acting anticholinergic bronchodilator primarily used in the management of chronic obstructive pulmonary disease (COPD) and asthma. As a deuterated compound, Tiotropium-d3 bromide contains three deuterium atoms, which are isotopes of hydrogen, enhancing its stability and allowing for more precise tracking in pharmacokinetic studies. The presence of bromide indicates that the compound is a salt form, which can influence its solubility and bioavailability. Tiotropium itself works by inhibiting the action of acetylcholine on muscarinic receptors in the airways, leading to relaxation of bronchial smooth muscle and improved airflow. The deuterated version is particularly useful in research settings for studying drug metabolism and distribution without interference from the non-deuterated form. Overall, Tiotropium-d3 bromide serves as a valuable tool in both clinical and research applications, contributing to a better understanding of respiratory therapies.

Formula: C₁₉H₂₂BrNO₄S₂

Synonyms:

• (1α,2β,4β,5α,7β)-7-[(2-Hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-diMethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane-d3 BroMide
• Tiotropium-d3 Bromide
• [2H3]-Tiotropium Bromide
• Tiotropium bromide salt

Tiotropium-d3 Bromide(N-methyl-d3)

CAS: 1127226-56-5

Purity: 99 atom % D

Color and Shape: White Solid

Molecular weight: 475.43

Ref: 3U-D7323

Tiotropium-d3 Bromide

Controlled Product

CAS: 1127226-56-5

Stability Not Stable in hot solution
Applications Muscarinic receptor antagonist. Bronchodilator.
References Haddad, E.-B., et al.: Mol. Pharmacol., 45, 899 (1994), Donohue, J. F., et al.: Chest, 122, 47 (2002), Profita, M., et al.: Allergy, 60, 1361 (2005), Dusser, D., et al.: Eur. Respir. J., 27, 547 (2006),

Formula: C₁₉D₃H₁₉NO₄S₂·Br

Color and Shape: White To Light Brown

Molecular weight: 475.43

Ref: TR-T444852