CAS 112733-06-9

Zenarestat

Description:

Zenarestat, with the CAS number 112733-06-9, is a chemical compound primarily studied for its potential therapeutic applications, particularly in the context of diabetes and related metabolic disorders. It functions as an aldose reductase inhibitor, which means it inhibits the enzyme responsible for converting glucose into sorbitol, thereby potentially reducing complications associated with diabetes, such as neuropathy and retinopathy. Zenarestat is characterized by its specific molecular structure, which includes functional groups that facilitate its interaction with the aldose reductase enzyme. The compound has been evaluated in various preclinical and clinical studies, demonstrating its pharmacological effects and safety profile. Its solubility, stability, and bioavailability are important factors that influence its efficacy as a therapeutic agent. As with many pharmaceutical compounds, ongoing research continues to explore its full potential and mechanisms of action, as well as any side effects or interactions with other medications.

Formula: C₁₇H₁₁BrClFN₂O₄

InChI: InChI=1/C17H11BrClFN2O4/c18-10-2-1-9(13(20)5-10)7-22-16(25)12-4-3-11(19)6-14(12)21(17(22)26)8-15(23)24/h1-6H,7-8H2,(H,23,24)

InChI key: InChIKey=SXONDGSPUVNZLO-UHFFFAOYSA-N

SMILES: C(C(O)=O)N1C=2C(C(=O)N(CC3=C(F)C=C(Br)C=C3)C1=O)=CC=C(Cl)C2

Synonyms:

• 1(2H)-Quinazolineacetic acid, 3,4-dihydro-3-((4-bromo-2-fluorophenyl)methyl)-7-chloro-2,4-dioxo-
• 1(2H)-Quinazolineacetic acid, 3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-3,4-dihydro-2,4-dioxo-
• 2-(7-Chloro-3-(4-bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro-2,4-dioxoquinazolin)-1-acetic acid
• 3-((4-Bromo-2-fluorophenyl)methyl)-7-chloro-3,4-dihydro-2,4-dioxo-1(2H)-quinazolineacetic acid
• 3-(4-Bromo-2-fluorobenzyl)-7-chloro-3,4-dihydro-2,4-dioxo-1(2H)-quinazolineacetic acid
• Ci 1014
• Fk 366
• Fr 74366
• Unii-180C9Pj8Jt
• Zenarestat [USAN:INN]
• Zenarestatum
• Zenarestatum [INN-Latin]
• [3-(4-bromo-2-fluorobenzyl)-7-chloro-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]acetic acid
• Zenarestat
• CI1014
• [3-(4-Bromo-2-fluorobenzyl)-7-chloro-2,4-dioxo-3,4-dihydro-1(2H)- quinazolinyl]acetic acid
• 2-[3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4-dioxoquinazolin-1-yl]acetic acid

Zenarestat

CAS: 112733-06-9

Zenarestat is an orally active aldose reductase inhibitor capable of ameliorating diabetic peripheral neuropathy in rats with type 2 diabetes.

Formula: C₁₇H₁₁BrClFN₂O₄

Purity: 99.51% - 99.51%

Color and Shape: Solid

Molecular weight: 441.64

Ref: TM-T35299