CAS 1127442-82-3

IWR-1-endo

Description:

IWR-1-endo is a small molecule inhibitor primarily known for its role in the modulation of the Wnt signaling pathway, which is crucial for various biological processes, including cell proliferation and differentiation. This compound is characterized by its ability to selectively inhibit the activity of the protein Dishevelled, thereby preventing the activation of downstream Wnt target genes. IWR-1-endo is often utilized in research settings to study the implications of Wnt signaling in developmental biology and cancer. The substance is typically presented as a solid and is soluble in organic solvents, making it suitable for in vitro experiments. Its mechanism of action and specificity make it a valuable tool for investigating the complexities of cellular signaling pathways. Additionally, due to its potential therapeutic implications, IWR-1-endo has garnered interest in the context of drug development, particularly in targeting diseases associated with aberrant Wnt signaling. As with any chemical substance, proper handling and safety protocols should be observed when working with IWR-1-endo in laboratory settings.

IWR-1

CAS: 1127442-82-3

Formula: C₂₅H₁₉N₃O₃

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Brown powder to crystal

Molecular weight: 409.45

Ref: 3B-I1167

IWR-1-endo

CAS: 1127442-82-3

Formula: C₂₅H₁₉N₃O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 409.4367

Ref: IN-DA00792N

IWR-1

CAS: 1127442-82-3

IWR-1

Purity: ≥98%

Molecular weight: 409.44g/mol

Ref: 54-BUP13379

IWR-1 [Optimized for Cell Culture]

CAS: 1127442-82-3

Formula: C₂₅H₁₉N₃O₃

Color and Shape: White to Brown powder to crystal

Molecular weight: 409.45

Ref: 3B-I1264

IWR-1

CAS: 1127442-82-3

IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).

Formula: C₂₅H₁₉N₃O₃

Purity: 99.19% - 99.82%

Color and Shape: Solid

Molecular weight: 409.44

Ref: TM-T2651

IWR-1-endo

CAS: 1127442-82-3

Ref: 7W-GW9762

IWR-1

Controlled Product

CAS: 1127442-82-3

Applications IWR-3 act as inhibitors of Wnt response. It appear that IWR compounds induce stabilization of Axin proteins via a direct interaction, which is a part of the b-catenin destruction complex (consists of Apc, Axin, Ck1 and Gsk3b).Such compounds may be used in the treatment of Wnt protein signaling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
References Lepourcelet, M., et al.: Cancer Cell., 5, 91 (2004), Clevers, H., et al.: Cell, 127, 469 (2006), Jin, G., et al.: Bioorg. Med. Chem. Lett., 19, 606 (2009),

Formula: C₂₅H₁₉N₃O₃

Color and Shape: Neat

Molecular weight: 409.437

Ref: TR-I941800

endo-IWR 1

CAS: 1127442-82-3

Stabilises axin protein of Wnt signalling pathway

Formula: C₂₅H₁₉N₃O₃

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 409.44 g/mol

Ref: 3D-FI24746