CAS 1127442-87-8

4-[(3aR,4R,7S,7aS-rel)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide

CAS: 1127442-87-8

Formula: C₂₅H₁₉N₃O₃

Purity: %

Color and Shape: Solid

Molecular weight: 409.4367

Ref: IN-DA008SRY

exo-IWR-1

CAS: 1127442-87-8

exo-IWR-1

Purity: ≥95%

Molecular weight: 409.44g/mol

Ref: 54-BUP10505

exo-IWR-1

CAS: 1127442-87-8

exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin

Formula: C₂₅H₁₉N₃O₃

Purity: 97.41%

Color and Shape: Solid

Molecular weight: 409.44

Ref: TM-T22775

exo-IWR-1

Controlled Product

CAS: 1127442-87-8

Applications exo-IWR-1 is the enantiomer of IWR-1 (I941800). exo-IWR-1 is an SAR anticancer Wnt response inhibitor. Such compounds may be used in the treatment of Wnt protein signaling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
References Lepourcelet, M., et al.: Cancer Cell, 5, 91 (2004), Barker, N., et al.: Nat. Rev. Drug Disc., 5, 997 (2006), Clevers, H., et al.: Cell, 127, 469 (2006), Jin, G., et al.: Bioorg. Med. Chem. Lett., 19, 606 (2009),

Formula: C₂₅H₁₉N₃O₃

Color and Shape: Neat

Molecular weight: 409.437

Ref: TR-I941805

exo-IWR-1

CAS: 1127442-87-8

Negative control for endo-IWR-1

Formula: C₂₅H₁₉N₃O₃

Purity: Min. 95%

Molecular weight: 409.44 g/mol

Ref: 3D-FE23213