CAS 112806-33-4

amitriptyline N-glucuronide

Description:

Amitriptyline N-glucuronide is a metabolite of the tricyclic antidepressant amitriptyline, which is primarily used to treat depression and certain types of pain. This compound is formed through the process of glucuronidation, where a glucuronic acid molecule is conjugated to amitriptyline, enhancing its solubility and facilitating excretion. The chemical structure of amitriptyline N-glucuronide features a glucuronic acid moiety linked to the nitrogen atom of the amitriptyline molecule. This modification typically results in altered pharmacokinetic properties, such as reduced bioactivity compared to the parent drug. Amitriptyline N-glucuronide is primarily found in biological fluids, such as urine, and is often monitored in pharmacokinetic studies to understand the metabolism of amitriptyline. Its presence can indicate the metabolic processing of the drug and may have implications for understanding individual responses to amitriptyline therapy. As with many metabolites, the specific biological effects and interactions of amitriptyline N-glucuronide are less well-characterized than those of the parent compound.

Formula: C₂₆H₃₁NO₆

InChI: InChI=1/C26H31NO6/c1-27(2,25-23(30)21(28)22(29)24(33-25)26(31)32)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12,21-25,28-30H,7,13-15H2,1-2H3/t21-,22-,23+,24-,25+/m0/s1

Synonyms:

• AT-N-Gluc
• 1-Propanaminium, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-beta-D-glucopyranuronosyl-N,N-dimethyl-, hydroxide, inner salt
• (2S,3S,4S,5R,6R)-6-{[3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)propyl](dimethyl)ammonio}-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate (non-preferred name)
• Amitriptyline N-glucuronide
• Amitriptyline-N-glucuronide

Amitriptyline N-Glucuronide

CAS: 112806-33-4

Formula: C₂₆H₃₁NO₆

Color and Shape: White To Off-White Solid

Molecular weight: 453.54

Ref: 4Z-A-207

Amitriptyline N-β-D-Glucuronide

Controlled Product

CAS: 112806-33-4

Formula: C₂₆H₃₁NO₆

Color and Shape: Neat

Molecular weight: 453.53

Ref: TR-A633360

Amitriptyline N-β-D-Glucuronide-d3

Controlled Product

CAS: 112806-33-4

Formula: C₂₆D₃H₂₈NO₆

Color and Shape: Neat

Molecular weight: 456.546

Ref: TR-A633367

Amitriptyline N-β-D-Glucuronide

CAS: 112806-33-4

Formula: C₁₉H₂₁N

Molecular weight: 453.54

Ref: ST-EA-CP-A39010