CAS 112809-51-5: Letrozole
Description:Letrozole is a non-steroidal aromatase inhibitor primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. Its mechanism of action involves the inhibition of aromatase, an enzyme responsible for converting androgens into estrogens, thereby reducing estrogen levels in the body. This reduction is crucial as many breast cancers are fueled by estrogen. Letrozole is typically administered orally and is known for its relatively favorable side effect profile compared to other hormonal therapies. Common side effects may include hot flashes, joint pain, fatigue, and potential bone density loss. The chemical structure of letrozole includes a triazole ring, contributing to its pharmacological properties. It is classified under the category of antineoplastic agents and is often part of adjuvant therapy following surgery or as a first-line treatment for advanced breast cancer. Letrozole's efficacy and safety have made it a standard option in breast cancer management, and ongoing research continues to explore its potential in other malignancies and therapeutic contexts.
Formula:C17H11N5
InChI:InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
InChI key:InChIKey=HPJKCIUCZWXJDR-UHFFFAOYSA-N
SMILES:N#CC1=CC=C(C=C1)C(C2=CC=C(C#N)C=C2)N3N=CN=C3
- Synonyms:
- 4,4'-(1h-1,2,4-Triazol-1-Ylmethylene) Bis-Benzonitrile
- 4,4'-(1h-1,2,4-Triazol-1-Ylmethylene)Bisbenzonitrile
- 4,4′-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile
- 4-[1-(4-Cyanophenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile
- Benzonitrile, 4,4′-(1H-1,2,4-triazol-1-ylmethylene)bis-
- Cgs 20267
- Femara
- Lelrozol
- Lerozole
- Letocor
- See more synonyms
- Letoripe
- Letrazole
- Letrof L Lil
- Letroz
- Letrozol
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Letrozole
Ref: 3B-L0248
1g | 119.00 € |
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Letrozole
Ref: AC-46319
1g | To inquire |
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Ref: 41-Y0000685
80mg | 115.00 € |
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Letrozole
Ref: 47-1234
100mg | 242.00 € |
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Letrozole
Ref: 45-1356971
200mg | 463.00 € |
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Letrozole
Ref: TM-T1590
25mg | 37.00 € | ||
50mg | 50.00 € |
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4,4'-((1H-1,2,4-Triazol-1-yl)methylene)dibenzonitrile
- 5-membered Heterocycles
- Triazoles
- Antitumoral
- Enzyme Activators and Inhibitors
- See more categories
- Active Pharmaceutical Ingredients (API) for research
- Enzymes
- Other Inhibitors
- Cancer Research
- Active Pharmaceutical Ingredient (API) Related Compounds for Research
- Biochemicals and Reagents
- Cellular and Molecular Biology
Ref: IN-DA0078V9
1g | 54.00 € | ||
5g | 97.00 € | ||
25g | 182.00 € | ||
100g | 486.00 € |
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Letrozole
Ref: 4Z-L-163
5mg | To inquire | ||
10mg | To inquire | ||
25mg | To inquire | ||
50mg | To inquire | ||
100mg | To inquire |
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Letrozole
Controlled ProductRef: 86-MM1143.00-0250
250mg | 781.00 € |
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Letrozole
Ref: 7W-GP1426
1g | 109.00 € | ||
100mg | 53.00 € |
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1-[Bis(4-cyanophenyl)methyl]-1,2,4-triazole
Ref: 10-F036495
1g | 39.00 € | ||
5g | 94.00 € | ||
25g | 265.00 € | ||
100g | To inquire |
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Letrozole
Ref: TR-L330100
10mg | 119.00 € | ||
25mg | 135.00 € | ||
50mg | 234.00 € |
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Letrozole - Bio-X ™
Controlled ProductRef: 3D-BL164620
50mg | 147.00 € |
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Letrozole
Controlled ProductRef: 3D-FL24873
25g | 351.00 € | ||
50g | 546.00 € | ||
100g | 990.00 € |
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Letrozole
Controlled ProductRef: 3D-Q-201291
1kg | To inquire | ||
50g | To inquire | ||
100g | To inquire | ||
250g | To inquire | ||
500g | To inquire |