CAS 112809-51-5: Letrozole

Description: Letrozole is a non-steroidal aromatase inhibitor primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. Its mechanism of action involves the inhibition of aromatase, an enzyme responsible for converting androgens into estrogens, thereby reducing estrogen levels in the body. This reduction is crucial as many breast cancers are fueled by estrogen. Letrozole is typically administered orally and is known for its relatively favorable side effect profile compared to other hormonal therapies. Common side effects may include hot flashes, joint pain, fatigue, and potential bone density loss. The chemical structure of letrozole includes a triazole ring, contributing to its pharmacological properties. It is classified under the category of antineoplastic agents and is often part of adjuvant therapy following surgery or as a first-line treatment for advanced breast cancer. Letrozole's efficacy and safety have made it a standard option in breast cancer management, and ongoing research continues to explore its potential in other malignancies and therapeutic contexts.

Formula: C₁₇H₁₁N₅

InChI: InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H

InChI key: InChIKey=HPJKCIUCZWXJDR-UHFFFAOYSA-N

SMILES: N#CC1=CC=C(C=C1)C(C2=CC=C(C#N)C=C2)N3N=CN=C3

Synonyms:

• 4,4'-(1h-1,2,4-Triazol-1-Ylmethylene) Bis-Benzonitrile
• 4,4'-(1h-1,2,4-Triazol-1-Ylmethylene)Bisbenzonitrile
• 4,4′-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile
• 4-[1-(4-Cyanophenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile
• Benzonitrile, 4,4′-(1H-1,2,4-triazol-1-ylmethylene)bis-
• Cgs 20267
• Femara
• Lelrozol
• Lerozole
• Letocor
• Letoripe
• Letrazole
• Letrof L Lil
• Letroz
• Letrozol
• Letrozole

Letrozole

CAS: 112809-51-5

• Formula: C₁₇H₁₁N₅
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 285.31

Letrozole

CAS: 112809-51-5

• Formula: C₁₇H₁₁N₅
• Purity: 100.0%
• Color and Shape: Yellow
• Molecular weight: 285.10145

Letrozole CRS

CAS: 112809-51-5

Letrozole

CAS: 112809-51-5

Aromatic or modified aromatic drugs with nitrogen hetero-atom(s) only, not elsewhere specified or included

• Formula: C₁₇H₁₁N₅
• Color and Shape: White Yellow Crystalline Powder
• Molecular weight: 285.10145

Letrozole

CAS: 112809-51-5

Letrozole (CGS 20267) is an Aromatase Inhibitor. The mechanism of action of letrozole is as …

• Formula: C₁₇H₁₁N₅
• Purity: 98.67% - 99.84%
• Color and Shape: White To Off-Whitecrystalline Powder
• Molecular weight: 285.3

4,4'-((1H-1,2,4-Triazol-1-yl)methylene)dibenzonitrile

CAS: 112809-51-5

• Formula: C₁₇H₁₁N₅
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 285.3027

Letrozol

CAS: 112809-51-5

• Molecular weight: 285.31g/mol

Letrozole

CAS: 112809-51-5

• Formula: C₁₇H₁₁N₅
• Color and Shape: White To Off-White Solid
• Molecular weight: 285.31

Letrozole

CAS: 112809-51-5

• Formula: C₁₇H₁₁N₅
• Color and Shape: Neat
• Molecular weight: 285.30

Letrozole

CAS: 112809-51-5

• Formula: C₁₇H₁₁N₅
• Color and Shape: Neat
• Molecular weight: 285.30

Letrozole

CAS: 112809-51-5

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₁₇H₁₁N₅
• Color and Shape: White to light yellow, Crystalline powder
• Molecular weight: 285.31

Letrozole

CAS: 112809-51-5

• Formula: C₁₇H₁₁N₅
• Purity: ≥ 98.0% (anhydrous basis)
• Color and Shape: White to off-white powder
• Molecular weight: 285.30

Letrozole

CAS: 112809-51-5

Applications A nonsteroidal aromatase inhibitor structurally related to Fadrozole. Antineoplastic. References Bhatnagar, A.S., et al: …

• Formula: C₁₇H₁₁N₅
• Color and Shape: Yellow
• Molecular weight: 285.30

1-[Bis(4-cyanophenyl)methyl]-1,2,4-triazole

CAS: 112809-51-5

• Purity: 97.0%
• Color and Shape: Solid
• Molecular weight: 285.30999755859375

Letrozole - Bio-X ™

CAS: 112809-51-5

Letrozole is an aromatase inhibitor drug that is used in the treatment of breast cancer …

• Formula: C₁₇H₁₁N₅
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 285.3 g/mol

Letrozole

CAS: 112809-51-5

Non-steroidal inhibitor of aromatase

• Formula: C₁₇H₁₁N₅
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 285.3 g/mol

Letrozole

CAS: 112809-51-5

Non-steroidal inhibitor of aromataseÂ

• Formula: C₁₇H₁₁N₅
• Molecular weight: 285.30 g/mol