CAS 112811-59-3: Gatifloxacin
Description:Gatifloxacin is a synthetic fluoroquinolone antibiotic characterized by its broad-spectrum antibacterial activity. It is primarily used to treat various bacterial infections, particularly those affecting the respiratory tract and urinary system. The chemical structure of gatifloxacin includes a bicyclic core with a fluorine atom, which enhances its potency against gram-positive and gram-negative bacteria. It exhibits a mechanism of action that involves the inhibition of bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and repair. Gatifloxacin is typically administered orally and is known for its good bioavailability. However, it has been associated with potential side effects, including gastrointestinal disturbances and, in rare cases, tendon damage. Its use has declined in some regions due to safety concerns and the emergence of bacterial resistance. As with all antibiotics, it is essential to use gatifloxacin judiciously to minimize the risk of resistance development and to ensure its effectiveness in treating infections.
Formula:C19H22FN3O4
InChI:InChI=1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26)
InChI key:InChIKey=XUBOMFCQGDBHNK-UHFFFAOYSA-N
SMILES:O=C(O)C1=CN(C2=C(OC)C(=C(F)C=C2C1=O)N3CCNC(C)C3)C4CC4
- Synonyms:
- 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Methoxy-7-(3-Methyl-1-Piperazinyl)-4-Oxo-3-Quinolinecarboxylic Acid
- 1-Cyclopropyl-6-Fluoro-8-Methoxy-7-(3-Methylpiperazin-1-Yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid
- 1-Cyclopropyl-6-fluoro-8-methoxy-1,4-dihydro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
- 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
- 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-4-ium-1-yl)-4-oxoquinoline-3-carboxylate
- 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-
- Am 1155
- Bms 206584-01
- G-Cebran
- Gaity
- See more synonyms
- Gatiflo
- Gatifloxin
- Gatilox
- Gatiquin
- Gatispan
- Pd 135432
- Tequin
- Tymer
- Zymar
- Zymaxid
