CAS 112828-15-6

(R)-Naproxen Acyl-b-D-glucuronide

Description:

(R)-Naproxen Acyl-β-D-glucuronide is a metabolite of the nonsteroidal anti-inflammatory drug (NSAID) naproxen, which is commonly used for its analgesic and anti-inflammatory properties. This compound is characterized by its glucuronide conjugation, which enhances its solubility and facilitates excretion from the body. The structure features a naproxen moiety linked to a β-D-glucuronic acid unit, resulting in a polar compound that is typically more water-soluble than its parent drug. This transformation is part of the phase II metabolic process, where drugs are conjugated to glucuronic acid to increase their elimination. The (R) configuration indicates the specific stereochemistry of the naproxen portion, which is important for its biological activity. As a metabolite, (R)-Naproxen Acyl-β-D-glucuronide may exhibit different pharmacokinetic and pharmacodynamic properties compared to naproxen itself, influencing its therapeutic effects and potential side effects. Understanding this compound is crucial for evaluating the metabolism and efficacy of naproxen in clinical settings.

Formula: C₂₀H₂₂O₉

InChI: InChI=1/C20H22O9/c1-9(10-3-4-12-8-13(27-2)6-5-11(12)7-10)19(26)29-20-16(23)14(21)15(22)17(28-20)18(24)25/h3-9,14-17,20-23H,1-2H3,(H,24,25)/t9-,14-,15-,16-,17?,20-/m1/s1

SMILES: C[C@H](c1ccc2cc(ccc2c1)OC)C(=O)O[C@@H]1[C@@H]([C@@H]([C@H](C(C(=O)O)O1)O)O)O

Synonyms:

• (R)-Naproxen Acyl--D-glucuronide
• (R)-Naproxen Glucuronide
• 1-[(aR)-6-Methoxy-a-methyl-2-naphthaleneacetate] -D-Glucopyranuronic Acid

(R)-Naproxen acyl-b-D-glucuronide

CAS: 112828-15-6

Ref: 7W-GC5773

(R)-Naproxen Acyl-β-D-glucuronide

Controlled Product

CAS: 112828-15-6

Stability Hygroscopic
Applications A metabolite of Naproxen.
References Boynton, C., et al.: J. Clin. Pharmacol., 28, 512 (1988), Jin, C., et al.: J. Pharmacol. Exp. Ther., 264, 475 (1993),King, C., et al.: Toxicol. Sci., 61, 49 (2001), Aresta, A., et al.: J. Pharm. Biomed. Anal., 39, 643 (2005),

Formula: C₂₀H₂₂O₉

Color and Shape: Neat

Molecular weight: 406.38

Ref: TR-N377515

(R)-Naproxen acyl-β-D-glucuronide

CAS: 112828-15-6

(R)-Naproxen acyl-β-D-glucuronide is an organic compound that is synthesized from naproxen. It may be used for the treatment of osteoarthritis, rheumatoid arthritis, and other inflammatory conditions. The synthesis of (R)-Naproxen acyl-β-D-glucuronide has been described in a number of publications. This compound is a synthetic, modified naproxen with high purity and custom synthesis options. The synthesis process includes Click modification, fluorination, glycosylation, methylation, and oligosaccharide modification. The final product is a white to off-white solid with high purity and low impurities.

Formula: C₂₀H₂₂O₉

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 406.38 g/mol

Ref: 3D-MN07306