CAS 112848-47-2
:Vancomycin,22-O-(3-amino-2,3,6-trideoxy-3-C-methyl-a-L-arabino-hexopyranosyl)-10,19-didechloro-, (4''R)-
Description:
Vancomycin, 22-O-(3-amino-2,3,6-trideoxy-3-C-methyl-a-L-arabino-hexopyranosyl)-10,19-didechloro-, (4''R)- is a complex glycopeptide antibiotic derived from the bacterium Amycolatopsis orientalis. This compound is characterized by its unique structure, which includes a core vancomycin backbone modified with a specific sugar moiety, enhancing its antibacterial activity. The presence of the 3-amino-2,3,6-trideoxy sugar contributes to its mechanism of action, which involves inhibiting bacterial cell wall synthesis by binding to the D-alanyl-D-alanine terminus of peptidoglycan precursors. This modification also influences its pharmacokinetics and spectrum of activity, making it effective against Gram-positive bacteria, including resistant strains like MRSA. The didechloro substitutions at positions 10 and 19 further modify its properties, potentially affecting its binding affinity and stability. Overall, this compound exemplifies the intricate relationship between chemical structure and biological function in antibiotic design, showcasing the importance of glycosylation in enhancing therapeutic efficacy.
Formula:C73H90N10O26
Synonyms:- Antibiotic A 82846C
- Orienticin C
- 22H-8,11:18,21-Dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H,16H-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine,vancomycin deriv.
- A 82846C
- Dechloroeremomycin
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