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CAS 112849-27-1

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Bis-TBDMS-trans-calcipotriol

Description:
Bis-TBDMS-trans-calcipotriol, with the CAS number 112849-27-1, is a synthetic derivative of calcipotriol, which is a vitamin D analog used primarily in dermatology for the treatment of psoriasis. This compound features two tert-butyldimethylsilyl (TBDMS) groups, which enhance its stability and lipophilicity, facilitating better skin penetration and prolonged action. The presence of these silyl groups also aids in protecting the hydroxyl functionalities from metabolic degradation. Bis-TBDMS-trans-calcipotriol exhibits similar biological activity to calcipotriol, promoting keratinocyte differentiation and inhibiting excessive proliferation, which is crucial in managing psoriatic lesions. Its trans configuration is significant for maintaining the desired biological activity. The compound is typically characterized by its solid-state properties, including melting point and solubility, which are influenced by the bulky TBDMS groups. Overall, Bis-TBDMS-trans-calcipotriol represents a modified approach to enhance the therapeutic efficacy of calcipotriol while minimizing potential side effects associated with its use.
Formula:C39H68O3Si2
InChI:InChI=1/C39H68O3Si2/c1-27(16-23-35(40)30-18-19-30)33-21-22-34-29(15-14-24-39(33,34)9)17-20-31-25-32(41-43(10,11)37(3,4)5)26-36(28(31)2)42-44(12,13)38(6,7)8/h16-17,20,23,27,30,32-36,40H,2,14-15,18-19,21-22,24-26H2,1,3-13H3/b23-16+,29-17+,31-20+/t27-,32-,33-,34+,35-,36?,39?/m1/s1
Synonyms:
  • 24-Cycloproyply-1,3-bis[[(1,1-dimethylethyl)dimethylsily]oxy]-9,10-secochola-5,7,10(19),22-tetraen-24-ol
  • Cyclopropanemethanol, a-[(1E,3R)-3-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-buten-1-yl]-, (aS)-
  • trans-calcipotriol-bis-TBDMS-ether
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