CAS 112953-11-4

UCN-01

Description:

UCN-01, also known by its chemical name, is a small molecule that has garnered attention in the field of cancer research due to its potential therapeutic properties. It is classified as a selective inhibitor of the protein kinase CK2, which plays a crucial role in various cellular processes, including cell proliferation and survival. UCN-01 has been studied for its ability to induce apoptosis in cancer cells and enhance the efficacy of other chemotherapeutic agents. The compound exhibits a unique mechanism of action by disrupting the signaling pathways that cancer cells rely on for growth and survival. In addition to its anti-cancer properties, UCN-01 has shown promise in modulating the immune response, making it a candidate for combination therapies. Its pharmacokinetic profile and safety profile have been evaluated in clinical settings, contributing to its potential as a valuable addition to cancer treatment regimens. However, further research is necessary to fully understand its efficacy and optimize its use in clinical applications.

Formula: C₂₈H₂₆N₄O₄

InChI: InChI=1/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18+,25-,27-,28+/m1/s1

InChI key: InChIKey=PBCZSGKMGDDXIJ-HQCWYSJUSA-N

SMILES: C[C@]12N3C=4C5=C(C6=C(C4C=7C3=CC=CC7)[C@@H](O)NC6=O)C=8C(N5[C@](O1)(C[C@@H](NC)[C@H]2OC)[H])=CC=CC8

Synonyms:

• (3R,9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• (5S,6R,7R,9R,16R)-16-hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
• (5S,6R,7R,9S,16R)-16-hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
• 7-Hydroxystaurosporine
• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-, (3R,9S,10R,11R,13R)-
• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-, [3R-(3α,9β,10α,11α,13β)]-
• Krx-0601
• Kw-2401
• NSC 638850
• Unc 01
• UCN 01
• KRX-0601，UCN-01
• (5S,6R,7R,9R,16R)-16-Hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-17-oxa
• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lM]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-3-hydroxy-10-Methoxy-9-Methyl-11-(MethylaMino)-, (3R,9S,10R,11R,13R)-
• (9S)-2,3,10,11,12,13-Hexahydro-3α-hydroxy-10α-methoxy-9-methyl-11α-methylamino-9β,13β-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one

UCN-01

CAS: 112953-11-4

Formula: C₂₈H₂₆N₄O₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 482.5304

Ref: IN-DA008U1Z

7-alfa-Hydroxystaurosporine (UCN-01)

CAS: 112953-11-4

Formula: C₂₈H₂₆N₄O₄

Color and Shape: Pale Yellow Solid

Molecular weight: 482.54

Ref: 4Z-S-172003

UCN-01

CAS: 112953-11-4

Formula: C₂₈H₂₆N₄O₄

Molecular weight: 482.53

Ref: 7W-GK4435

UCN 01

Controlled Product

CAS: 112953-11-4

Formula: C₂₈H₂₆N₄O₄

Color and Shape: Neat

Molecular weight: 482.53

Ref: TR-U130615

UCN-01

CAS: 112953-11-4

UCN-01 is a basic protein that has been shown to induce apoptosis in vitro. It binds to DNA and inhibits the activity of kinases, which are enzymes that regulate cellular processes such as the cell cycle. UCN-01 can also bind to human α1-acid glycoprotein, which is involved in inflammation and coagulation. This drug is currently being studied for its potential use as an inhibitor of cancer cells.

Formula: C₂₈H₂₆N₄O₄

Purity: Min. 95%

Molecular weight: 482.53 g/mol

Ref: 3D-MEA95311

Midostaurin Impurity 2

CAS: 112953-11-4

Formula: C₂₈H₂₆N₄O₄

Molecular weight: 482.5

Ref: ST-EA-CP-M107012

UCN-01

CAS: 112953-11-4

inhibitor of Akt, protein kinase C, PDK1 and cyclin-dependent kinases

Formula: C₂₈H₂₆N₄O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 482.53

Ref: TM-T23495