CAS 112965-21-6

Calcipotriol

Description:

Calcipotriol, also known as calcipotriene, is a synthetic derivative of vitamin D3, primarily used in dermatology for the treatment of psoriasis. It functions as a potent modulator of skin cell proliferation and differentiation, helping to reduce the excessive growth of skin cells associated with this condition. Calcipotriol exhibits a high affinity for the vitamin D receptor, which mediates its biological effects. The substance is typically formulated as a topical ointment, cream, or solution, allowing for localized treatment with minimal systemic absorption. Its chemical structure features a steroid-like backbone with specific modifications that enhance its therapeutic efficacy while minimizing side effects. Calcipotriol is generally well-tolerated, though it may cause mild local irritation in some patients. It is often used in combination with other treatments, such as corticosteroids, to enhance therapeutic outcomes. As with any medication, it is essential to follow prescribed guidelines to ensure safety and effectiveness.

Formula: C₂₇H₄₀O₃

InChI: InChI=1S/C27H40O3/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2/h6-7,10,13,17,20,22-26,28-30H,2,4-5,8-9,11-12,14-16H2,1,3H3/b13-6+,19-7+,21-10-/t17-,22-,23-,24+,25-,26+,27-/m1/s1

InChI key: InChIKey=LWQQLNNNIPYSNX-UROSTWAQSA-N

SMILES: C[C@@]12[C@](\C(=C\C=C\3/C(=C)[C@@H](O)C[C@H](O)C3)\CCC1)(CC[C@@]2([C@@H](/C=C/[C@@H](O)C4CC4)C)[H])[H]

Synonyms:

• (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-Cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol
• (1S,3R,5Z,7E,13xi,14xi,17xi,22E,24R)-26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraene-1,3,24-triol
• (1S,3R,5Z,7E,14xi,22E,24S)-26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraene-1,3,24-triol
• (1S,3R,5Z,7E,22E)-26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraene-1,3,24-triol
• (1S,3R,5Z,7E,22E,24S)-26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraene-1,3,24-triol
• 1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)-
• 24-Cyclopropyl-(1Alpha,3Beta,5Z,7E,22E,24S)-9,10-Secochola-5,7,10(19),22-Tetraene-1,3,24-Triol
• 5Z,7E,22E,24S)--Bet
• 9,10-Secochola-5,7,10(19),22-Tetraene-1,3,24-Triol,24-Cyclopropyl-,(1-Alpha,3
• 9,10-Secochola-5,7,10(19),22-tetraene-1,3,24-triol, 24-cyclopropyl-, (1α,3β,5Z,7E,22E,24S)-
• Calcipotriol
• Calcipotriol anhydrous
• Calciptriol
• Calciptriol, MC-903, Daivonex, Dovonex, Psorcutan
• Daivonex
• Dovonex
• Mc 903
• Mc903
• Pri 2201

Calcipotriene

CAS: 112965-21-6

Other cyclanic, cyclenic or cycloterpenic alcohols and their halogenated, sulfonated, nitrated or nitrosated derivatives

Formula: C₂₇H₄₀O₃

Color and Shape: White Off-White Powder

Molecular weight: 412.29775

Ref: 45-1086141

Calcipotriol

CAS: 112965-21-6

Calcipotriol (MC 903) is a synthetic vitamin D3 analogue with high affinity for the vitamin D receptor. High-Quality, Low-Cost!

Formula: C₂₇H₄₀O₃

Purity: 98.05% - 99.07%

Color and Shape: White Crystalline Solid

Molecular weight: 412.6

Ref: TM-T14856

Calcipotriol (Calcipotriene)

CAS: 112965-21-6

Formula: C₂₇H₄₀O₃

Color and Shape: White To Off-White Solid

Molecular weight: 412.61

Ref: 4Z-C-148001

Calcipotriol-d4 (Calcipotriene-d4)

CAS: 112965-21-6

Formula: C₂₇H₃₆D₄O₃

Molecular weight: 416.64

Ref: 4Z-C-148009

Calcipotriol, anhydrous

CAS: 112965-21-6

Formula: C₂₇H₄₀O₃

Purity: (HPLC) 95.5 - 102.0 %

Color and Shape: White to off-white crystalline powder

Molecular weight: 412.6 (anhydrous)

Ref: 7W-GP8730

Calcipotriol

CAS: 112965-21-6

Calcipotriol

Purity: ≥98%

Molecular weight: 412.6g/mol

Ref: 54-BUP06266

Calcipotriene

CAS: 112965-21-6

Stability Light and Temperature Sensitive
Applications An antipsoriatic. A vitamin D3 analogue with low calcemic activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Binderup, L. and Bramm, E.: Biochem. Pharmacol., 37, 889 (1988), Valaja, T., et al.: Biochem. Pharmacol., 40, 1827 (1990), Ashcroft, D.M., et al.: Brit Med. J., 320, 963 (2000), Ghoreishi, M., et al.: J. Immunol., 182, 6071 (2009), Sato, T., et al.: J. Med. Chem., 51, 7705 (2008),

Formula: C₂₇H₄₀O₃

Color and Shape: Neat

Molecular weight: 412.60

Ref: TR-C144200

Calcipotriol

CAS: 112965-21-6

Calcipotriol is a vitamin D analogue that is used to treat psoriasis. It is classified as an aprotic solvent and is not soluble in water, but it dissolves in organic solvents. Calcipotriol binds to the receptor for nuclear factor kappa-B (NF-κB) and inhibits its activation, which suppresses the production of cytokines that are involved in inflammation and immune responses. The calcipotriol molecule has been shown to inhibit EGFR signaling, thereby suppressing tumor growth. This drug has also been shown to be effective in combination therapy with other drugs such as dithranol or anthralin for the treatment of psoriasis. Calcipotriol can be administered topically or by oral administration. It is usually applied twice daily and the dosage depends on the severity of the disease.

Formula: C₂₇H₄₀O₃

Purity: Min. 95 Area-%

Color and Shape: White Powder

Molecular weight: 412.6 g/mol

Ref: 3D-FC19634

Calcipotriene-d4

Controlled Product

CAS: 112965-21-6

Formula: C₂₇D₄H₃₆O₃

Color and Shape: Neat

Molecular weight: 416.629

Ref: TR-C144202