CAS 1130115-44-4

Sorafenib-d3

Description:

Sorafenib-d3 is a deuterated form of Sorafenib, a multi-kinase inhibitor primarily used in the treatment of certain cancers, including renal cell carcinoma and hepatocellular carcinoma. The "d3" designation indicates that this compound contains three deuterium atoms, which are isotopes of hydrogen, replacing the regular hydrogen atoms in the molecule. This modification can enhance the stability and tracking of the compound in metabolic studies. Sorafenib itself works by inhibiting various kinases involved in tumor growth and angiogenesis, thereby impeding cancer progression. The deuterated version is often utilized in pharmacokinetic studies to better understand the drug's behavior in biological systems. Sorafenib-d3 retains similar pharmacological properties to its non-deuterated counterpart, making it a valuable tool in research settings. Its molecular structure includes a pyridine ring and a urea moiety, contributing to its activity against specific targets in cancer cells. Overall, Sorafenib-d3 serves as an important compound in both therapeutic applications and scientific research.

Formula: C₂₁H₁₆ClF₃N₄O₃

Synonyms:

• [2H3]-Sorafenib
• SORAFENIB D3 (BAY 43-9006 D3)
• 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-(trideuteriomethyl)pyridine-2-carboxamide
• Donafenib Tosylate

Sorafenib-d3

CAS: 1130115-44-4

Formula: C₂₁H₁₃D₃ClF₃N₄O₃

Color and Shape: Off-White To Grey Solid

Molecular weight: 467.85

Ref: 4Z-S-274

Donafenib

CAS: 1130115-44-4

Donafenib

Purity: ≥98%

Molecular weight: 467.84g/mol

Ref: 54-BUP05292

Donafenib

CAS: 1130115-44-4

Donafenib(Bay 43-9006 (D3)) is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3,

Formula: C₂₁H₁₃ClD₃F₃N₄O₃

Purity: 99.88%

Color and Shape: Solid

Molecular weight: 467.84

Ref: TM-T16909

Sorafenib-d3

Controlled Product

CAS: 1130115-44-4

Formula: C₂₁₂H₃H₁₃ClF₃N₄O₃

Color and Shape: Light Beige Solid

Molecular weight: 467.84

Ref: TR-S676852

Sorafenib-d3

CAS: 1130115-44-4

Formula: C₂₁H₁₃ClD₃F₃N₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 467.8434

Ref: IN-DA008VTR