CAS 113082-98-7

Enalkiren

Description:

Enalkiren is a chemical compound classified as a non-peptide angiotensin II receptor antagonist, primarily investigated for its potential use in treating hypertension and heart failure. It functions by inhibiting the action of angiotensin II, a peptide hormone that plays a crucial role in regulating blood pressure and fluid balance. Enalkiren is characterized by its ability to selectively bind to the angiotensin II type 1 receptor, thereby blocking its effects and promoting vasodilation. The compound is typically administered orally and has been studied for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion. Its safety profile and efficacy have been evaluated in various clinical trials, although it has not achieved widespread clinical use. As with many pharmacological agents, potential side effects may include dizziness, hypotension, and electrolyte imbalances. Overall, enalkiren represents a significant area of research in cardiovascular pharmacotherapy, contributing to the understanding of blood pressure regulation and the development of novel antihypertensive agents.

Formula: C₃₅H₅₆N₆O₆

InChI: InChI=1S/C35H56N6O6/c1-22(2)15-30(42)32(44)27(16-23-9-7-6-8-10-23)40-34(46)29(18-25-20-37-21-38-25)41-33(45)28(39-31(43)19-35(3,4)36)17-24-11-13-26(47-5)14-12-24/h11-14,20-23,27-30,32,42,44H,6-10,15-19,36H2,1-5H3,(H,37,38)(H,39,43)(H,40,46)(H,41,45)/t27-,28-,29-,30-,32+/m0/s1

InChI key: InChIKey=KQXVERRYBYGQJZ-WRPDIKACSA-N

SMILES: [C@H](CC1=CN=CN1)(C(N[C@@H](CC2CCCCC2)[C@H]([C@H](CC(C)C)O)O)=O)NC([C@H](CC3=CC=C(OC)C=C3)NC(CC(C)(C)N)=O)=O

Synonyms:

• (alphaS)-alpha-((alphaS)-alpha-(3-Amino-3-methylbutyramido)-p-methoxyhydrocinnamamido)-N-((1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)imidazole-4-propionamide
• <span class="text-smallcaps">L</smallcap>-Histidinamide, N-(3-amino-3-methyl-1-oxobutyl)-O-methyl-<smallcap>L</span>-tyrosyl-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-
• <span class="text-smallcaps">L</smallcap>-Histidinamide, N-(3-amino-3-methyl-1-oxobutyl)-O-methyl-<smallcap>L</span>-tyrosyl-N-[1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-, [1S-(1R*,2S*,3R*)]-
• A 64662
• Abbott 64662
• Enalkiren [USAN:INN]
• Enalkirene
• Enalkirene [INN-French]
• Enalkirenum
• Enalkirenum [INN-Latin]
• Enalquireno
• Enalquireno [INN-Spanish]
• L-Histidinamide, N-(3-amino-3-methyl-1-oxobutyl)-O-methyl-L-tyrosyl-N-(1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)-, (1S-(1R*,2S*,3R*))-
• N-(3-Amino-3-methyl-1-oxobutyl)-O-methyl-<span class="text-smallcaps">L</smallcap>-tyrosyl-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-<smallcap>L</span>-histidinamide
• N-(3-amino-3-methylbutanoyl)-O-methyl-L-tyrosyl-N-[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]-L-histidinamide
• Unii-0U7Yz42Z47
• Enalkiren
• N-(3-Amino-3-methyl-1-oxobutyl)-O-methyl-L-tyrosyl-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-histidinamide

Enalkiren

CAS: 113082-98-7

Enalkiren is a dipeptide renin inhibitor used in treating cogenstive heart failure. Enalkiren causes a prolonged reduction in blood pressure.

Formula: C₃₅H₅₆N₆O₆

Color and Shape: Solid

Molecular weight: 656.86

Ref: TM-T27261