CAS 113145-69-0

(S)-(+)-Niguldipine hydrochloride

Description:

(S)-(+)-Niguldipine hydrochloride is a calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. As a chiral compound, it exhibits stereoisomerism, with the (S)-enantiomer being the active form that interacts effectively with calcium channels in vascular smooth muscle. This substance is characterized by its ability to inhibit the influx of calcium ions, leading to vasodilation and reduced blood pressure. It is typically administered in its hydrochloride salt form, which enhances its solubility and bioavailability. The compound has a specific molecular structure that contributes to its pharmacological activity, and it is often evaluated for its efficacy and safety in clinical settings. Additionally, (S)-(+)-Niguldipine hydrochloride may exhibit side effects common to calcium channel blockers, such as peripheral edema or dizziness. Its use is subject to medical supervision, and it is important to consider potential drug interactions and contraindications when prescribing this medication.

Formula: C₃₆H₄₀ClN₃O₆

Synonyms:

• (S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester hydrochloride
• (S)(+)Niguldipine hydrochloride,(S) (+) Niguldipine hydrochloride

(S)-(+)-Niguldipine hydrochloride

CAS: 113145-69-0

(S)-(+)-Niguldipine hydrochloride

Purity: ≥98%

Molecular weight: 646.17g/mol

Ref: 54-BUP03819

S-(+)-Niguldipine hydrochloride

CAS: 113145-69-0

Niguldipine hydrochloride is a novel prodrug of the calcium channel blocker, niguldipine. This drug is an ATP-binding cassette transporter substrate that inhibits bowel disease by binding to the transporter protein, thereby blocking its activity. The drug has been shown to have low potency and is not effective against infectious diseases. Niguldipine hydrochloride may act as an autophagy inducer, which may reduce the number of cancer cells in human osteosarcoma cells. It also has been shown to inhibit receptor activity in air entrainment models.

Formula: C₃₆H₄₀ClN₃O₆

Purity: Min. 95%

Molecular weight: 646.2 g/mol

Ref: 3D-NEA14569

(S)-(+)-Niguldipine hydrochloride

CAS: 113145-69-0

(S)-(+)-Niguldipine hydrochloride is a selective α1A-AR antagonist used in the study of depression and epilepsy.

Formula: C₃₆H₄₀ClN₃O₆

Purity: 98.27%

Color and Shape: Solid

Molecular weight: 646.17

Ref: TM-T23301