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CAS 113165-32-5

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Niguldipine

Description:
Niguldipine is a pharmaceutical compound classified as a calcium channel blocker, primarily used in the treatment of hypertension and angina pectoris. It belongs to the dihydropyridine class of calcium antagonists, which work by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissue. This action leads to vasodilation, reducing peripheral resistance and lowering blood pressure. Niguldipine is characterized by its ability to selectively target vascular tissues, minimizing effects on cardiac contractility. The compound is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Its chemical structure includes a dihydropyridine ring, which is essential for its pharmacological activity. As with other calcium channel blockers, potential side effects may include headache, dizziness, flushing, and peripheral edema. It is important for patients to consult healthcare professionals for appropriate use and monitoring while on this medication.
Formula:C36H39N3O6
InChI:InChI=1/C36H39N3O6/c1-25-31(34(40)44-3)33(27-12-10-17-30(24-27)39(42)43)32(26(2)37-25)35(41)45-23-11-20-38-21-18-36(19-22-38,28-13-6-4-7-14-28)29-15-8-5-9-16-29/h4-10,12-17,24,33,37H,11,18-23H2,1-3H3/t33-/m0/s1
SMILES:CC1=C([C@H](c2cccc(c2)N(=O)=O)C(=C(C)N1)C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C(=O)OC
Synonyms:
  • Niguldipine [INN]
  • Unii-Z81N45O25Z
  • (-)-(S)-3-(4,4-Diphenylpiperidino)propyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
  • 3-(4,4-Diphenylpiperidin-1-Yl)Propyl Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
  • 3-(4,4-diphenylpiperidin-1-yl)propyl methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
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