CAS 113243-00-8

[1S,(+)]-2,3,4,9-Tetrahydro-6-fluoro-9-(4-chlorobenzyl)-1H-carbazole-1-acetic acid

Description:

[1S,(+)]-2,3,4,9-Tetrahydro-6-fluoro-9-(4-chlorobenzyl)-1H-carbazole-1-acetic acid is a synthetic organic compound characterized by its complex structure, which includes a carbazole core, a fluorine atom, and a chlorobenzyl substituent. This compound features a tetrahydro configuration, indicating it has a saturated ring system, which contributes to its stability and potential biological activity. The presence of the fluorine atom often enhances lipophilicity, potentially influencing its pharmacokinetic properties. The chlorobenzyl group may impart specific interactions with biological targets, making it of interest in medicinal chemistry. The compound's chiral center, denoted by the (S) configuration, suggests that it may exhibit stereoselective behavior in biological systems, which is crucial for its efficacy and safety in therapeutic applications. Overall, this compound's unique structural features may contribute to its potential use in drug development, particularly in areas requiring targeted action against specific biological pathways.

Formula: C₂₁H₁₉ClFNO₂

Synonyms:

• 2-[(1S)-9-[(4-chlorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl]acetic acid
• 1H-Carbazole-1-acetic acid, 9-[(4-chlorophenyl)methyl]-6-fluoro-2,3,4,9-tetrahydro-, (1S)-
• L-657926
• [1S,(+)]-2,3,4,9-Tetrahydro-6-fluoro-9-(4-chlorobenzyl)-1H-carbazole-1-acetic acid
• 1H-Carbazole-1-aceticacid, 9-[(4-chlorophenyl)methyl]-6-fluoro-2,3,4,9-tetrahydro-, (S)-

L-657926

CAS: 113243-00-8

L-657926 is a stereoselective antagonist of the thromboxane A2 (TxA2) receptor, composed of (-)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid and (+)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid. The IC50 values for the (-) and (+) configurations against TxA2 are 0.27 nM and 124 nM, respectively.

Formula: C₂₁H₁₉ClFNO₂

Color and Shape: Solid

Molecular weight: 371.832

Ref: TM-T204805