CAS 1132709-15-9

B-[(1R)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid

Description:

B-[(1R)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid is a complex organic compound characterized by its boronic acid functional group, which is known for its ability to form reversible covalent bonds with diols. This compound features a chiral center, indicated by the (1R) and (2R) stereochemistry, which contributes to its potential biological activity and specificity in interactions. The presence of a phenyl group and a pyrazinylcarbonyl moiety suggests that it may exhibit significant interactions with biological targets, possibly in medicinal chemistry applications. The boronic acid group is often utilized in drug design for its ability to modulate enzyme activity and participate in molecular recognition processes. Additionally, the compound's structure indicates potential for use in targeted therapies, particularly in the context of cancer treatment or other diseases where specific enzyme inhibition is desired. Overall, this compound exemplifies the intricate relationship between molecular structure and biological function in pharmaceutical chemistry.

Formula: C₁₉H₂₅BN₄O₄

InChI: InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17+/m1/s1

InChI key: InChIKey=GXJABQQUPOEUTA-WBVHZDCISA-N

SMILES: [C@@H](CC1=CC=CC=C1)(C(N[C@@H](CC(C)C)B(O)O)=O)NC(=O)C=2C=NC=CN2

Synonyms:

• B-[(1R)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
• Boronic acid, B-[(1R)-3-methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]-
• Bortezomib impurity 1/(1R,2R)-Bortezomib
• Bortezomib 1R, 2R Isomer Q: What is the storage condition of
• Bortezomib USP RC A
• (1R,2R)-Bortezomib Impurity
• Bortezomib 1R, 2R Isomer Q: What are the applications of
• Bortezomib USP Related Compoud H
• Bortezomib Diastereomer (R,R)
• Bortizomib RR (Diastereomer)
• [(1R)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid
• ((R)-3-Methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid
• N-(2-Pyrazinecarbonyl)-D-phenylalanine-L-leucine boronic anhydride
• Bortezomib 1R, 2R Isomer
• Boron tezomio enantiomers (RR)
• Bortezomib 1R, 2R IsomerQ: What is
• [(1R)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
• Bortezomib Related Compound A/ Bortezomib Impurity D (Bortezomib R,R-Isomer Impurity)
• Bortezomib 1R, 2R Isomer Q: What is the CAS Number of
• (1R,2R)-BortezoMib

((R)-3-Methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid

CAS: 1132709-15-9

Formula: C₁₉H₂₅BN₄O₄

Purity: %

Color and Shape: Solid

Molecular weight: 384.2372

Ref: IN-DA008WR0

((R)-3-Methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid

CAS: 1132709-15-9

((R)-3-Methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid

Purity: 98%

Molecular weight: 384.25g/mol

Ref: 54-OR1065577

(1R,2R)-Bortezomib

CAS: 1132709-15-9

Formula: C₁₉H₂₅BN₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 384.24

Ref: 4Z-B-4677

(1R,2R)-Bortezomib

CAS: 1132709-15-9

Impurity Bortezomib USP Related Compound A
Applications (1R,2R)-Bortezomib is a diastereomer of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C.: Chem. and Eng. News, 87, 41 (2009)

Formula: C₁₉H₂₅BN₄O₄

Purity: >85%

Color and Shape: Neat

Molecular weight: 384.24

Ref: TR-B675705

Bortezomib Impurity (R,R-Isomer)

CAS: 1132709-15-9

Formula: C₁₉H₂₅BN₄O₄

Molecular weight: 384.24

Ref: ST-EA-CP-B34003