CAS 113277-37-5

Suc-Ala-Ala-Pro-Val-AMC

Description:

Suc-Ala-Ala-Pro-Val-AMC, also known as a peptide substrate, is a synthetic compound commonly used in biochemical research, particularly in studies involving proteases and enzyme activity. This compound features a sequence of amino acids, specifically succinylated alanine, proline, and valine, linked to an AMC (7-amino-4-methylcoumarin) fluorophore, which allows for fluorescence-based detection. The succinyl group enhances the solubility and stability of the peptide in aqueous solutions. The presence of the AMC moiety enables the compound to release a fluorescent signal upon cleavage by specific enzymes, making it a valuable tool for monitoring proteolytic activity in various biological assays. Its characteristics include being a white to off-white solid, soluble in water and organic solvents, and exhibiting stability under standard laboratory conditions. The compound is primarily utilized in research settings to study enzyme kinetics and mechanisms, contributing to our understanding of proteolytic processes in biological systems.

Formula: C₃₀H₃₉N₅O₉

Synonyms:

• L-Valinamide, N-(3-carboxy-1-oxopropyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- (9CI)
• Suc-AAPV-AMC
• SUC-ALA-ALA-PRO-VAL-AMC
• L-Valinamide,N-(3-carboxy-1-oxopropyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-

Suc-Ala-Ala-Pro-Val-AMC

CAS: 113277-37-5

Suc-AAPV-AMC, substrate for human neutrophil elastase.

Formula: C₃₀H₃₉N₅O₉

Purity: > 98%

Color and Shape: White Powder

Molecular weight: 613.67

Ref: 01-4015705

Suc-Ala-Ala-Pro-Val-AMC

CAS: 113277-37-5

Suc-Ala-Ala-Pro-Val-AMC is a protease inhibitor that inhibits serine proteases by binding to the reactive site. It has been shown to inhibit prorenin, a renin enzyme that is involved in the regulation of blood pressure and kidney function. Suc-Ala-Ala-Pro-Val-AMC has also been shown to inhibit thrombin, which is involved in blood coagulation, and neutrophil elastase, which is responsible for the degradation of elastin fibers. Suc-Ala-Ala-Pro-Val-AMC has been shown to be effective against babesiosis, an infection caused by the protozoan parasite Babesia microti. This drug is expected to have a neutral pH and high detection sensitivity when used in clinical settings.

Formula: C₃₀H₃₉N₅O₉

Purity: Min. 95%

Molecular weight: 613.66 g/mol

Ref: 3D-FS110545