CAS 1132935-63-7

Dasabuvir

Description:

Dasabuvir is an antiviral medication primarily used in the treatment of hepatitis C virus (HCV) infections. It functions as a non-nucleoside polymerase inhibitor, specifically targeting the NS5B polymerase enzyme, which is crucial for viral replication. Dasabuvir is characterized by its ability to disrupt the viral life cycle, thereby reducing the viral load in infected individuals. The compound is typically administered in combination with other antiviral agents to enhance efficacy and prevent resistance. In terms of its chemical structure, Dasabuvir features a complex arrangement of functional groups that contribute to its pharmacological activity. It is generally well-tolerated, but like all medications, it may have side effects, which can vary among individuals. The drug is often part of a direct-acting antiviral regimen, reflecting the trend in modern antiviral therapies to utilize combinations of agents for improved treatment outcomes. Overall, Dasabuvir represents a significant advancement in the management of hepatitis C, contributing to higher cure rates and improved patient quality of life.

Formula: C₂₆H₂₇N₃O₅S

InChI: InChI=1S/C26H27N3O5S/c1-26(2,3)22-15-20(29-11-10-23(30)27-25(29)31)14-21(24(22)34-4)18-7-6-17-13-19(28-35(5,32)33)9-8-16(17)12-18/h6-15,28H,1-5H3,(H,27,30,31)

InChI key: InChIKey=NBRBXGKOEOGLOI-UHFFFAOYSA-N

SMILES: O(C)C1=C(C=C(C=C1C(C)(C)C)N2C(=O)NC(=O)C=C2)C3=CC4=C(C=C3)C=C(NS(C)(=O)=O)C=C4

Synonyms:

• Dasabuvir
• Methanesulfonamide, N-[6-[5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-3-(1,1-dimethylethyl)-2-methoxyphenyl]-2-naphthalenyl]-
• N-(6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide
• N-[6-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]naphthalen-2-yl]methanesulfonamide
• N-[6-[5-(3,4-Dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-3-(1,1-dimethylethyl)-2-methoxyphenyl]-2-naphthalenyl]methanesulfonamide
• ABT 333

ABT-333

CAS: 1132935-63-7

Formula: C₂₆H₂₇N₃O₅S

Purity: 98%

Color and Shape: Solid

Molecular weight: 493.5747

Ref: IN-DA008TD8

Dasabuvir

CAS: 1132935-63-7

Dasabuvir

Purity: ≥98%

Molecular weight: 493.57g/mol

Ref: 54-BUP05987

Dasabuvir

CAS: 1132935-63-7

Formula: C₂₆H₂₇N₃O₅S

Molecular weight: 493.59

Ref: 4Z-D-156001

Dasabuvir

CAS: 1132935-63-7

Dasabuvir (ABT-333) blocks HCV replication by inhibiting the essential NS5B RNA polymerase.

Formula: C₂₆H₂₇N₃O₅S

Purity: 99.54% - 99.62%

Color and Shape: Solid

Molecular weight: 493.57

Ref: TM-T3489

Dasabuvir-13C-d3

CAS: 1132935-63-7

Formula: C₂₆H₂₄N₃O₅SD₃

Molecular weight: 497.59

Ref: 4Z-D-156003

Dasabuvir-d9

CAS: 1132935-63-7

Formula: C₂₆H₁₈N₃O₅SD₉

Molecular weight: 502.64

Ref: 4Z-D-156002

Dasabuvir

CAS: 1132935-63-7

Dasabuvir is a non-nucleoside NS5B polymerase inhibitor with action on hepatitis C virus RNA replication and is used for treating hepatitis C in combination therapies.

Formula: C₂₆H₂₇N₃O₅S

Purity: Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 493.58 g/mol

Ref: 3D-FD64996

N-(6-(3-(TERT-BUTYL)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-2-METHOXYPHENYL)NAPHTHALEN-2-YL)METHANESULFONAMIDE

CAS: 1132935-63-7

Purity: 98%

Molecular weight: 493.5799866

Ref: 10-F793990

Dasabuvir O-Trideuteromethyl-d3

Controlled Product

CAS: 1132935-63-7

Formula: C₂₆D₃H₂₄N₃O₅S

Color and Shape: Neat

Molecular weight: 496.593

Ref: TR-D193553

Dasabuvir Naphthyl-d6

Controlled Product

CAS: 1132935-63-7

Formula: C₂₆D₆H₂₁N₃O₅S

Color and Shape: Neat

Molecular weight: 499.612

Ref: TR-D193552

Dasabuvir

Controlled Product

CAS: 1132935-63-7

Applications Dasabuvir is an antiviral drug used in the treatment of chronic hepatitis C virus (HCV) infection.
References Khatri, A., et al.: J. Hepatol., 63, 805 (2015);

Formula: C₂₆H₂₇N₃O₅S

Color and Shape: Neat

Molecular weight: 493.57

Ref: TR-D193550