CAS 1132940-11-4

Methanesulfonamide, N-[6-[5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-3-(1,1-dimethylethyl)-2-methoxyphenyl]-2-naphthalenyl]-, sodium salt (1:1)

Description:

Methanesulfonamide, N-[6-[5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-3-(1,1-dimethylethyl)-2-methoxyphenyl]-2-naphthalenyl]-, sodium salt (1:1) is a complex organic compound characterized by its sulfonamide functional group, which is known for its antibacterial properties. The presence of a sodium salt indicates that it is likely soluble in water, enhancing its bioavailability in pharmaceutical applications. The compound features a pyrimidine ring, which contributes to its potential biological activity, and multiple aromatic systems that may influence its interaction with biological targets. The presence of methoxy and tert-butyl groups suggests that the compound may exhibit lipophilic characteristics, potentially affecting its pharmacokinetics. Overall, this compound's structural complexity and functional groups suggest it may have applications in medicinal chemistry, particularly in the development of therapeutic agents. However, specific biological activity, toxicity, and stability would require further investigation through empirical studies.

Formula: C₂₆H₂₇N₃O₅S·Na

InChI: InChI=1S/C26H27N3O5S.Na/c1-26(2,3)22-15-20(29-11-10-23(30)27-25(29)31)14-21(24(22)34-4)18-7-6-17-13-19(28-35(5,32)33)9-8-16(17)12-18;/h6-15,28H,1-5H3,(H,27,30,31);

InChI key: InChIKey=CNUGIPSJLQIKHL-UHFFFAOYSA-N

SMILES: O(C)C1=C(C=C(C=C1C(C)(C)C)N2C(=O)NC(=O)C=C2)C3=CC4=C(C=C3)C=C(NS(C)(=O)=O)C=C4.[Na]

Synonyms:

• Methanesulfonamide, N-[6-[5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-3-(1,1-dimethylethyl)-2-methoxyphenyl]-2-naphthalenyl]-, sodium salt (1:1)
• N-[6-[3-tert-Butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl]naphthalen-2-yl]methanesulfonamide monosodium salt

Dasabuvir sodium

CAS: 1132940-11-4

Dasabuvir sodium (ABT-333) inhibits HCV NS5B polymerase, targeting genotypes 1a (EC50: 7.7 nM) and 1b (EC50: 1.8 nM).

Formula: C₂₆H₂₆N₃NaO₅S

Color and Shape: Solid

Molecular weight: 515.56

Ref: TM-T63593