CAS 113299-38-0

(S)-BICALUTAMIDE

Description:

(S)-Bicalutamide is a non-steroidal anti-androgen medication primarily used in the treatment of prostate cancer. It functions by selectively inhibiting the action of androgens, such as testosterone, at the androgen receptor level, thereby impeding the growth of androgen-dependent tumors. The compound is characterized by its chiral nature, with the (S)-enantiomer being the active form that exhibits higher potency compared to its (R)-counterpart. Bicalutamide is typically administered orally and is known for its relatively long half-life, allowing for once-daily dosing. Its chemical structure includes a biphenyl moiety and a substituted amide group, contributing to its pharmacological properties. Common side effects may include hot flashes, gastrointestinal disturbances, and potential liver function alterations. Due to its mechanism of action, (S)-Bicalutamide is often used in combination with other therapies, such as luteinizing hormone-releasing hormone (LHRH) agonists, to enhance treatment efficacy in advanced prostate cancer cases.

Formula: C₁₈H₁₄F₄N₂O₄S

Synonyms:

• (S)-Casodex
• Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-, (2S)-
• Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-, (S)-
• (2S)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
• ICI-187556
• (2S)-N-[3-(Trifluoromethyl)-4-cyanophenyl]-2-methyl-2-hydroxy-3-(4-fluorophenylsulfonyl)propanamide
• BicalutaMide S-IsoMer
• (S)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide

S-Bicalutamide

CAS: 113299-38-0

Formula: C₁₈H₁₄F₄N₂O₄S

Molecular weight: 430.38

Ref: 4Z-B-024

(S)-Bicalutamide

CAS: 113299-38-0

Color and Shape: Neat

Ref: 86-MM0894.26

(S)-Bicalutamide

Controlled Product

CAS: 113299-38-0

Applications (S)-Enantiomer of Bicalutamide. Used as an antiandrogen, antineoplastic (hormonal).
References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990), Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),

Formula: C₁₈H₁₄F₄N₂O₄S

Color and Shape: White

Molecular weight: 430.37

Ref: TR-B382010

(S)-Bicalutamide

CAS: 113299-38-0

Androgen receptor antagonist; anti-cancer agent

Formula: C₁₈H₁₄F₄N₂O₄S

Purity: Min. 97 Area-%

Molecular weight: 430.37 g/mol

Ref: 3D-FB18583

Bicalutamide S-Isomer

CAS: 113299-38-0

Formula: C₁₈H₁₄F₄N₂O₄S

Molecular weight: 430.37

Ref: ST-EA-CP-B12043