CAS 113299-40-4
:(R)-BICALUTAMIDE
Description:
(R)-Bicalutamide is a non-steroidal anti-androgen medication primarily used in the treatment of prostate cancer. It functions by selectively inhibiting the action of androgens, such as testosterone, at the androgen receptor level, thereby impeding the growth of androgen-dependent tumors. The compound is characterized by its chiral nature, with the (R)-enantiomer being the active form that exhibits higher potency compared to its (S)-counterpart. Bicalutamide has a relatively high oral bioavailability and is typically administered in tablet form. Its chemical structure includes a 4'-nitro-3'-trifluoromethylphenyl moiety, contributing to its pharmacological properties. The substance is metabolized in the liver, with its metabolites being excreted primarily through urine. Common side effects may include hot flashes, gastrointestinal disturbances, and potential liver function alterations. Due to its mechanism of action, (R)-Bicalutamide is often used in combination with other therapies, such as luteinizing hormone-releasing hormone (LHRH) agonists, to enhance treatment efficacy in advanced prostate cancer cases.
Formula:C18H14F4N2O4S
InChI:InChI=1/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)/t17-/m0/s1
SMILES:C[C@](CS(=O)(=O)c1ccc(cc1)F)(C(=Nc1ccc(C#N)c(c1)C(F)(F)F)O)O
Synonyms:- R-Bicalutimide
- (2R)-N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Fluorophenyl)Sulfonyl]-2-Hydroxy-2-Methylpropanamide
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Found 10 products.
(R)-(-)-Bicalutamide-d4
CAS:Formula:C18H10D4F4N2O4SColor and Shape:White To Off-White SolidMolecular weight:373.41Bicalutamide EP Impurity K
CAS:Formula:C24H20F6N4O6SColor and Shape:White To Off-White SolidMolecular weight:606.50(R)-Bicalutamide
CAS:Controlled Product<p>Applications (R)-Enantiomer of Bicalutamide. Used as an antiandrogen, antineoplastic (hormonal).<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990), Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),<br></p>Formula:C18H14F4N2O4SColor and Shape:WhiteMolecular weight:430.37(R)-Bicalutamide
CAS:<p>Androgen receptor antagonist; anti-cancer agent</p>Formula:C18H14F4N2O4SPurity:Min. 95%Color and Shape:PowderMolecular weight:430.37 g/mol(R)-Bicalutamide
CAS:(R)-Bicalutamide, an AR antagonist with antitumor properties, is crucial in prostate cancer research.Formula:C18H14F4N2O4SColor and Shape:SolidMolecular weight:430.37
