CAS 1133378-37-6

Darunavir-d9

CAS: 1133378-37-6

Formula: C₂₇H₂₈D₉N₃O₇S

Color and Shape: White To Off-White Solid

Molecular weight: 556.72

Ref: 4Z-D-372

Darunavir-d9 (iso-butyl-d9)(Darunavir)

CAS: 1133378-37-6

Purity: 99 atom % D

Molecular weight: 556.72

Ref: 3U-D7573

Darunavir-d9

Controlled Product

CAS: 1133378-37-6

Applications Second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.
References Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003), Arasteh, K., et al.: AIDS, 19, 943 (2005), Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005),

Formula: C₂₇₂H₉H₂₈N₃O₇S

Color and Shape: Off-White To Light Beige

Molecular weight: 556.72

Ref: TR-D193502

Darunavir-D9

CAS: 1133378-37-6

Darunavir-D9 is a prodrug of darunavir, which is an HIV protease inhibitor. Darunavir-D9 has been shown to be bioequivalent in pharmacokinetic parameters to darunavir given as a tablet. The drug exhibits a low plasma concentration profile and high clearance values. This may be due to rapid absorption and distribution of the drug, with a short elimination half-life. Darunavir-D9 also has little effect on the matrix effect and reproducibility of the reaction monitoring assay, making it an ideal candidate for use in clinical trials.

Formula: C₂₇H₂₈D₉N₃O₇S

Purity: Min. 95%

Molecular weight: 556.72 g/mol

Ref: 3D-IVB37837