CAS 1133387-60-6

Aprepitant-d4

CAS: 1133387-60-6

Formula: C₂₃H₁₇D₄F₇N₄O₃

Molecular weight: 538.46

Ref: 4Z-A-3259

Aprepitant-d4

Controlled Product

CAS: 1133387-60-6

Applications Aprepitant-d4 is a labeled analogue of Aprepitant (A729800), A novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Aprepitant-d4 is a potential treatment for chemotherapy induced nausea and vomiting.
References Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998); Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001); Van Belle, S., et al.: Cancer, 94, 3032 (2002); Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006)

Formula: C₂₃H₁₇D₄F₇N₄O₃

Color and Shape: Neat

Molecular weight: 538.45

Ref: TR-A729803

Aprepitant-d4

Controlled Product

CAS: 1133387-60-6

Aprepitant-d4 is a sample preparation reagent used in the analysis of neurokinin-1 receptor antagonists, such as aprepitant. It is a chromatographic reagent that has been shown to have a high level of sensitivity and specificity for detection. Aprepitant-d4 can be used in the analysis of HIV infection by monitoring for changes in neurokinin-1 (NK1) receptor levels. This reagent has also been shown to be specific for the detection of aprepitant by mass spectrometric methods, which are sensitive and selective. Aprepitant-d4 is an acetonitrile solution that dissolves aprepitant at concentrations up to 1 mg/mL with no significant solubility limitations.

Formula: C₂₃H₁₇D₄F₇N₄O₃

Purity: Min. 95%

Molecular weight: 538.45 g/mol

Ref: 3D-IVB38760