CAS 1133432-49-1: GDC 0834
Description:GDC 0834 is a small molecule inhibitor primarily developed for the treatment of various cancers, particularly those associated with mutations in the Hedgehog signaling pathway. It is classified as a selective antagonist of the Smoothened (SMO) receptor, which plays a crucial role in the Hedgehog signaling cascade that regulates cell growth and differentiation. The inhibition of SMO by GDC 0834 can lead to the suppression of tumor growth in cancers where this pathway is aberrantly activated. The compound is characterized by its specific binding affinity to the target receptor, which allows for a more targeted therapeutic approach with potentially fewer side effects compared to broader-spectrum chemotherapeutics. In preclinical studies, GDC 0834 has shown promise in inhibiting tumor proliferation and inducing apoptosis in cancer cell lines. Its development is part of ongoing research into targeted cancer therapies, aiming to improve treatment outcomes for patients with Hedgehog pathway-related malignancies. As with many investigational drugs, further clinical trials are necessary to fully establish its efficacy and safety profile.
Formula:C33H36N6O3S
InChI:InChI=1S/C33H36N6O3S/c1-20-24(9-7-10-25(20)36-31(40)28-18-22-8-5-6-11-27(22)43-28)26-19-39(4)33(42)30(35-26)34-23-14-12-21(13-15-23)29-32(41)38(3)17-16-37(29)2/h7,9-10,12-15,18-19,29H,5-6,8,11,16-17H2,1-4H3,(H,34,35)(H,36,40)/t29-/m1/s1
InChI key:InChIKey=CDOOFZZILLRUQH-GDLZYMKVSA-N
SMILES:O=C(NC1=CC=CC(C=2N=C(NC3=CC=C(C=C3)C4C(=O)N(C)CCN4C)C(=O)N(C2)C)=C1C)C=5SC6=C(C5)CCCC6
- Synonyms:
- GDC 0834
- N-[3-[6-[[4-[(2R)-1,4-Dimethyl-3-oxo-2-piperazinyl]phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamide
- Benzo[b]thiophene-2-carboxamide, N-[3-[6-[[4-[(2R)-1,4-dimethyl-3-oxo-2-piperazinyl]phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]-4,5,6,7-tetrahydro-
Brand | Product data | Purity | Price range | Estimated delivery |
---|---|---|---|---|
![]() | GDC-0834 REF: TM-T11379CAS: 1133432-49-1 | - - - | 135.00 €~518.00 € | Tue 11 Mar 25 |
![]() | GDC-0834 REF: 3D-IVB43249CAS: 1133432-49-1 | Min. 95% | To inquire | Mon 21 Apr 25 |
![]() | GDC0834 REF: IN-DA008TGECAS: 1133432-49-1 | % | - - - | Discontinued product |
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GDC-0834
Ref: TM-T11379
2mg | 188.00 € | ||
5mg | 379.00 € | ||
1mL*10mM (DMSO) | 518.00 € |
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GDC-0834
Ref: 3D-IVB43249
5mg | 776.00 € | ||
10mg | 1,168.00 € | ||
25mg | 1,903.00 € | ||
50mg | 3,045.00 € |
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Ref: IN-DA008TGE
1mg | Discontinued | Request information | |
2mg | Discontinued | Request information | |
5mg | Discontinued | Request information | |
10mg | Discontinued | Request information |