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GDC 0834

CAS 1133432-49-1: GDC 0834

Description:GDC 0834 is a small molecule inhibitor primarily developed for the treatment of various cancers, particularly those associated with mutations in the Hedgehog signaling pathway. It is classified as a selective antagonist of the Smoothened (SMO) receptor, which plays a crucial role in the Hedgehog signaling cascade that regulates cell growth and differentiation. The inhibition of SMO by GDC 0834 can lead to the suppression of tumor growth in cancers where this pathway is aberrantly activated. The compound is characterized by its specific binding affinity to the target receptor, which allows for a more targeted therapeutic approach with potentially fewer side effects compared to broader-spectrum chemotherapeutics. In preclinical studies, GDC 0834 has shown promise in inhibiting tumor proliferation and inducing apoptosis in cancer cell lines. Its development is part of ongoing research into targeted cancer therapies, aiming to improve treatment outcomes for patients with Hedgehog pathway-related malignancies. As with many investigational drugs, further clinical trials are necessary to fully establish its efficacy and safety profile.

Formula:C33H36N6O3S

InChI:InChI=1S/C33H36N6O3S/c1-20-24(9-7-10-25(20)36-31(40)28-18-22-8-5-6-11-27(22)43-28)26-19-39(4)33(42)30(35-26)34-23-14-12-21(13-15-23)29-32(41)38(3)17-16-37(29)2/h7,9-10,12-15,18-19,29H,5-6,8,11,16-17H2,1-4H3,(H,34,35)(H,36,40)/t29-/m1/s1

InChI key:InChIKey=CDOOFZZILLRUQH-GDLZYMKVSA-N

SMILES:O=C(NC1=CC=CC(C=2N=C(NC3=CC=C(C=C3)C4C(=O)N(C)CCN4C)C(=O)N(C2)C)=C1C)C=5SC6=C(C5)CCCC6

  • Synonyms:
  • GDC 0834
  • N-[3-[6-[[4-[(2R)-1,4-Dimethyl-3-oxo-2-piperazinyl]phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamide
  • Benzo[b]thiophene-2-carboxamide, N-[3-[6-[[4-[(2R)-1,4-dimethyl-3-oxo-2-piperazinyl]phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]-4,5,6,7-tetrahydro-
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GDC-0834

CAS:1133432-49-1

Ref: TM-T11379

2mg188.00 €
5mg379.00 €
1mL*10mM (DMSO)518.00 €
Estimated delivery in United States, on Tuesday 11 Mar 2025
discount label

GDC-0834

CAS:1133432-49-1

Ref: 3D-IVB43249

5mg776.00 €
10mg1,168.00 €
25mg1,903.00 €
50mg3,045.00 €
Estimated delivery in United States, on Monday 21 Apr 2025
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GDC0834

CAS:1133432-49-1

Discontinued product
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