CAS 1133695-49-4

Bazedoxifene-d4 Acetate

Description:

Bazedoxifene-d4 acetate is a deuterated form of bazedoxifene, a selective estrogen receptor modulator (SERM) primarily used in the treatment of postmenopausal osteoporosis and for alleviating menopausal symptoms. The "d4" designation indicates that the compound contains four deuterium atoms, which are isotopes of hydrogen, replacing regular hydrogen atoms in the molecular structure. This modification can enhance the stability and metabolic tracking of the compound in biological studies. Bazedoxifene-d4 acetate functions by selectively binding to estrogen receptors, exerting estrogenic effects in some tissues while antagonizing estrogen action in others, which helps in reducing the risk of estrogen-related cancers. The acetate moiety contributes to its pharmacokinetic properties, influencing absorption and distribution. As a research chemical, bazedoxifene-d4 acetate is often utilized in pharmacological studies to understand the mechanisms of action of SERMs and their potential therapeutic applications. Its unique isotopic labeling allows for precise tracking in metabolic studies, providing insights into its behavior in biological systems.

Formula: C₃₂H₃₈N₂O₅

Synonyms:

• 4
• 1-[[4-[2-(Hexahydro-1H-azepin-1-yl)ethoxy-1,1,2,2-d
• ]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol
• 1-[[4-[2-(Hexahydro-1H-azepin-1-yl)(ethoxy-d4)]phenyl]Methyl]-2-(4-hydroxyphenyl)-3-Methyl-
• Bazedoxifene-d4 Acetate
• [2H4]-Bazedoxifene

Bazedoxifene-d4

CAS: 1133695-49-4

Formula: C₃₀H₃₀D₄N₂O₃

Color and Shape: Pale Grey Solid

Molecular weight: 474.64

Ref: 4Z-B-482

Bazedoxifene-d4

Controlled Product

CAS: 1133695-49-4

Applications Bazedoxifene-d4 is a labeled nonsteroidal selective estrogen receptor modulator (SERM). Bazedoxifene is used as an antiosteoporotic.
References van Hoorn, W., et al.: J. Med. Chem., 45, 584 (2002); Neubauer, B., et al.: Cancer Res., 63, 6056 (2003); Yan, X., et al.: Biochemistry, 43, 909 (2004);

Formula: C₃₀H₃₀D₄N₂O₃

Color and Shape: Neat

Molecular weight: 474.627

Ref: TR-B129247

Bazedoxifene-d4 Acetate

Controlled Product

CAS: 1133695-49-4

Formula: C₃₀H₃₀D₄N₂O₃

Color and Shape: Neat

Molecular weight: 474.627

Ref: TR-B129252