CAS 1133712-26-1

Posaconazole-d4

Description:

Posaconazole-d4 is a deuterated form of posaconazole, an antifungal medication primarily used to prevent and treat fungal infections, particularly in immunocompromised patients. The "d4" designation indicates that four hydrogen atoms in the molecule have been replaced with deuterium, a stable isotope of hydrogen. This modification can enhance the compound's stability and alter its pharmacokinetic properties, making it useful in research applications, particularly in studies involving drug metabolism and pharmacodynamics. Posaconazole itself is known for its broad-spectrum activity against various fungi, including Aspergillus and Candida species. The deuterated version retains the core structure and functional groups of the original compound, which includes a triazole ring and a side chain that contribute to its antifungal activity. The use of deuterated compounds in research helps in tracing metabolic pathways and understanding the drug's behavior in biological systems. Overall, Posaconazole-d4 serves as a valuable tool in pharmacological studies while maintaining the essential characteristics of its parent compound.

Formula: C₃₇H₄₂F₂N₈O₄

Synonyms:

• Noxafil-d4
• 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]Methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol-d4
• Posacozole-d5
• [2H4]-Posaconazole
• Posaconazole-d4
• 2-[(2S,3S)-2-hydroxypentan-3-yl]-4-[2,3,5,6-tetradeuterio-4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one
• Sch 56592-d4
• Posaconazole A5
• POSACONAZOLE (D4, 98%) 1.0 MG/ML IN METHANOL

Posaconazole-D4

CAS: 1133712-26-1

Posaconazole-D4, a deuterium-labeled variant of Posaconazole, is a broad-spectrum, second-generation triazole with antifungal activity.

Formula: C₃₇H₄₂F₂N₈O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 704.8

Ref: TM-T12522

Posaconazole-d4

Controlled Product

CAS: 1133712-26-1

Applications Orally active labelled triazole antifungal.
References Cacciapuoti, A., et al.: Antimicrob. Agents Chemother., 44, 2017 (2000), Herbrecht, R., et al.: Int. J. Clin. Pract., 58, 612 (2004), Panackal, A., et al.: J. Clin. Microbiol., 44, 1740 (2006),

Formula: C₃₇H₃₈D₄F₂N₈O₄

Color and Shape: White To Light Grey

Molecular weight: 705.00

Ref: TR-P689602

Posaconazole-d4

CAS: 1133712-26-1

Formula: C₃₇H₃₈D₄F₂N₈O₄

Purity: ≥97%

Color and Shape: Solid

Molecular weight: 704.8020

Ref: IN-DA008VVY