8-OxoG Clamp CEP, with the CAS number 1134373-47-9, is a chemical compound that serves as a selective inhibitor of DNA polymerases, particularly those that incorporate nucleotides opposite the oxidized guanine base, 8-oxoguanine (8-OxoG). This compound is characterized by its ability to mimic the structure of nucleotides, allowing it to effectively bind to the active site of DNA polymerases. Its primary application lies in the study of DNA repair mechanisms and the role of oxidative stress in mutagenesis and cancer. The presence of the 8-oxoG moiety is significant as it is a common form of oxidative DNA damage, and the compound's design facilitates the investigation of how cells respond to such lesions. Additionally, 8-OxoG Clamp CEP may have implications in therapeutic strategies aimed at enhancing the efficacy of certain cancer treatments by targeting DNA repair pathways. Overall, this compound is a valuable tool in molecular biology and cancer research, providing insights into the complexities of DNA damage and repair.

8-OxoG Clamp CEP

1134373-47-9: 8-OxoG Clamp CEP, with the CAS number 1134373-47-9, is a chemical compound that serves as a selective inhibitor of DNA polymerases, particularly those that incorporate nucleotides opposite the oxidized guanine base, 8-oxoguanine (8-OxoG). This compound is characterized by its ability to mimic the structure of nucleotides, allowing it to effectively bind to the active site of DNA polymerases. Its primary application lies in the study of DNA repair mechanisms and the role of oxidative stress in mutagenesis and cancer. The presence of the 8-oxoG moiety is significant as it is a common form of oxidative DNA damage, and the compound's design facilitates the investigation of how cells respond to such lesions. Additionally, 8-OxoG Clamp CEP may have implications in therapeutic strategies aimed at enhancing the efficacy of certain cancer treatments by targeting DNA repair pathways. Overall, this compound is a valuable tool in molecular biology and cancer research, providing insights into the complexities of DNA damage and repair.

<p>Applications 8-OxoG Clamp CEP is a specific fluorescent probe for 8-oxo-deoxyguanosine (8-oxo-dG).<br>References Nasr, T., et al.: Bioorg. Med. Chem. Lett., 19, 727-730 (2009);<br></p>

CAS 1134373-47-9

8-OxoG Clamp CEP

8-OxoG Clamp CEP

Ref: TR-O856815