CAS 113507-06-5

Moxidectin

Description:

Moxidectin is a semi-synthetic macrocyclic lactone belonging to the class of compounds known as avermectins, which are derived from the fermentation of the bacterium Streptomyces avermitilis. It is primarily used as an antiparasitic agent, particularly in veterinary medicine, for the treatment of various parasitic infections in animals, including nematodes and ectoparasites. Moxidectin exhibits a broad spectrum of activity and is known for its prolonged duration of action, which allows for less frequent dosing compared to some other antiparasitic agents. The compound works by binding to glutamate-gated chloride channels in the nervous system of parasites, leading to paralysis and death of the organism. Moxidectin is typically administered orally or via injection, and its pharmacokinetics are characterized by good absorption and distribution in tissues. It is important to note that while Moxidectin is effective against many parasites, it is not effective against all, and its use should be guided by veterinary recommendations to ensure safety and efficacy.

Formula: C₃₇H₅₃NO₈

InChI: InChI=1/C37H53NO8/c1-21(2)14-25(6)33-26(7)31(38-42-8)19-36(46-33)18-29-17-28(45-36)13-12-23(4)15-22(3)10-9-11-27-20-43-34-32(39)24(5)16-30(35(40)44-29)37(27,34)41/h9-12,14,16,21-22,26,28-30,32-34,39,41H,13,15,17-20H2,1-8H3/b10-9+,23-12+,25-14+,27-11+,38-31-/t22-,26-,28+,29-,30-,32+,33+,34+,36-,37+/m0/s1

InChI key: InChIKey=YZBLFMPOMVTDJY-LSGXYNIPSA-N

SMILES: C(=C\C(C)C)(\C)/[C@H]1O[C@@]2(C[C@@]3(C[C@](O2)(C/C=C(\C)/C[C@@H](C)/C=C/C=C\4/[C@@]5(O)[C@](C(=O)O3)(C=C(C)[C@@H](O)[C@]5(OC4)[H])[H])[H])[H])C/C(=N\OC)/[C@@H]1C

Synonyms:

• (2aE,4E,4'E,5'S,6R,8E,11R,13R,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-4'-(methoxyimino)-5',6,8,19-tetramethyl-6'-[(2E)-4-methylpent-2-en-2-yl]-3',4',5',6,6',7,10,11,14,15,17a,20,20a,20b-tetradecahydro-2H,17H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-17-one
• (6R,23E,25S)-5-O-Demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-(methoxyimino)milbemycin B
• 23-Methoxime-LL-F 28249α
• 5-O-demethyl-28-deoxy-25-(1E)-1,3-dimethyl-1-butenyl-6,28-epoxy-23-(methoxyimino)-, (6R,23E,25S)-
• Cl 301423
• Cydectin
• Equest
• Milbemycin B, 5-O-demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-(methoxyimino)-, [6R,23E,25S(E)]-
• Milbemycin B, 5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-(methoxyimino)-, (6R,23E,25S)-
• Milbemycin B, 5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-butenyl]-6,28-epoxy-23-(methoxyimino)-, (6R,23E,25S)-
• MilbemycinB
• Moxidextin
• ProHeart 6
• Proheart
• Quest
• Quest (parasiticide)
• Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran], milbemycin B deriv.
• Vetdectin Oral Drench
• Moxidectin@100 μg/mL in Acetonitrile
• [6R,23E,25S(E)]-5-O-DeMethyl-28-deoxy-25-(1,3-diMethyl-1-butenyl)-6,28-epoxy-23-(MethoxyiMino)MilbeMycin B
• Moxidectin powder CAS 113507-06-5 fiona
• Moxidectin Solution, 100ppm
• Moxidectin CRS
• Moxidectin
• (1R,4S,4'E,5'S,6R,6'S,8R,10E,13R,14E,16E,20R,21R,24S)-21,24-dihydroxy-4'-methoxyimino-5',11,13,22-tetramethyl-6'-[(E)-4-methylpent-2-en-2-yl]spiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
• milbemycin B
• Moxidectin, >=98%
• (2R,2a'E,2a1'S,4Z,4'E,5S,6S,6'R,8'E,11'R,15'S,17a'R,20'R,20a'R)-2a1',20'-Dihydroxy-4-(methoxyimino)-5,6',8',19'-tetramethyl-6-((E)-4-methylpent-2-en-2-yl)-2a1',3,4,5,6,6',7',10',11',14',15',17a',20',20a'-tetradecahydro-2'H,17'H-spiro[pyran-2,13'-[11,15]methano[1,5]dioxacyclooctadecino[9,8,7-cd]benzofuran]-17'-one
• Milbemycin B,
• Moxidectin for system suitability CRS
• Milbemycin B,5-O-demethyl-28-deoxy-25-(1,3-dimethyl-1-buten-1-yl)-6,28-epoxy-23-(methoxyimino)-,(6R,23E,25S)-
• Moxidectin,MilbeMycin B,23-MethoxiMe-LL-F 28249α,Equest,ProHeart 6
• Moxidectin Solution in Methanol, 100μg/mL
• Moxdectin
• (6R,23E,25S)-5-O-DeMethyl-28-deoxy-25-[(1E)-1,3-diMethyl-1-buten-1-yl]-6,28-epoxy-23-(MethoxyiMino)
• Moxidectin HOUSE STANDARD

Moxidectin

CAS: 113507-06-5

Moxidectin is a milbemycin derivative that belongs to the class of macrocyclic lactones. It is used in veterinary medicine to treat infections caused by Diptera larvae, such as the sheep blowfly, Lucilia sericata. Moxidectin has been shown to be an effective drug against c. glabrata, which is resistant to ivermectin and other drugs. Moxidectin binds to P-glycoprotein substrate site 1 and prevents drug efflux from cells by competing with other substrates for binding sites on the transporter. This inhibition of drug efflux may be due to its ability to block P-glycoprotein function or act as a direct inhibitor of ATPase activity. The analytical method used in this study was high performance liquid chromatography (HPLC).

Formula: C₃₇H₅₃NO₈

Purity: Min. 92 Area-%

Color and Shape: White Powder

Molecular weight: 639.82 g/mol

Ref: 3D-FM31082

Moxidectin - Bio-X ™

CAS: 113507-06-5

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₃₇H₅₃NO₈

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 639.82 g/mol

Ref: 3D-BM300102