Bradykinin is a peptide that plays a significant role in various physiological processes, particularly in the regulation of blood pressure and inflammatory responses. The specific variant you mentioned, (hydroxy-Pro)(3)-Lys-bradykinin, is a modified form of bradykinin where the third proline residue is hydroxylated. This modification can influence the peptide's biological activity and stability. Bradykinin itself is composed of a chain of amino acids, typically consisting of nine residues, and is known for its potent vasodilatory effects, which contribute to increased vascular permeability and pain sensation. It acts primarily through the bradykinin receptors, B1 and B2, which are G-protein-coupled receptors. The presence of hydroxyproline in this variant may enhance its interaction with these receptors or alter its pharmacokinetic properties. Overall, bradykinin and its derivatives are of interest in pharmacology and therapeutic applications, particularly in the context of cardiovascular health and inflammatory diseases.

bradykinin, (hydroxy-Pro)(3)-Lys-

113662-39-8: Bradykinin is a peptide that plays a significant role in various physiological processes, particularly in the regulation of blood pressure and inflammatory responses. The specific variant you mentioned, (hydroxy-Pro)(3)-Lys-bradykinin, is a modified form of bradykinin where the third proline residue is hydroxylated. This modification can influence the peptide's biological activity and stability. Bradykinin itself is composed of a chain of amino acids, typically consisting of nine residues, and is known for its potent vasodilatory effects, which contribute to increased vascular permeability and pain sensation. It acts primarily through the bradykinin receptors, B1 and B2, which are G-protein-coupled receptors. The presence of hydroxyproline in this variant may enhance its interaction with these receptors or alter its pharmacokinetic properties. Overall, bradykinin and its derivatives are of interest in pharmacology and therapeutic applications, particularly in the context of cardiovascular health and inflammatory diseases.

Kallidin, 4-[(4R)-4-hydroxy-L-proline]-

<p>Lys-[Hyp3]-Bradykinin, a human urine-derived kinin and bradykinin agonist, is used for inflammation research.</p>

CAS 113662-39-8

bradykinin, (hydroxy-Pro)(3)-Lys-

Kallidin, 4-[(4R)-4-hydroxy-L-proline]-

Ref: IN-DA00098M

Lys-[Hyp3]-Bradykinin

Ref: TM-T76293