CAS 113759-50-5

Cronidipine

Description:

Cronidipine is a calcium channel blocker primarily used in the treatment of hypertension and certain cardiovascular conditions. It belongs to the dihydropyridine class of calcium antagonists, which work by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissue. This action leads to vasodilation, reducing peripheral resistance and lowering blood pressure. Cronidipine is characterized by its selective action on vascular smooth muscle, which minimizes effects on cardiac contractility and heart rate, making it suitable for patients with specific cardiovascular profiles. The compound is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Its pharmacokinetics may be influenced by factors such as food intake and individual metabolic variations. As with other medications in its class, potential side effects may include dizziness, flushing, and peripheral edema. Overall, Cronidipine represents a valuable option in the management of hypertension, particularly for patients requiring a well-tolerated and effective antihypertensive agent.

Formula: C₃₀H₃₂ClN₃O₈

InChI: InChI=1/C30H32ClN3O8/c1-18-25(28(35)39-3)27(20-5-4-6-23(15-20)34(37)38)26(19(2)32-18)29(36)40-16-24-17-41-30(42-24)11-13-33(14-12-30)22-9-7-21(31)8-10-22/h4-10,15,24,27,32H,11-14,16-17H2,1-3H3

Synonyms:

• [8-(4-chlorophenyl)-1,4-dioxa-8-azaspiro[4.5]dec-2-yl]methyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• Cronidipinum
• Cronidipine [INN]
• Cronidipinum [INN-Latin]
• (8-(p-Chlorophenyl)-1,4-dioxa-8-azaspiro(4,5)dec-2-yl)methyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
• Cronidipino [INN-Spanish]
• Cronidipino
• LF 2-0254
• UNII-7TXJ9MY5V9
• 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[8-(4-chlorophenyl)-1,4-dioxa-8-azaspiro[4.5]decan-2-yl]methyl 5-methyl ester
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[[8-(4-chlorophenyl)-1,4-dioxa-8-azaspiro[4.5]dec-2-yl]methyl] 5-methyl ester

Cronidipine

CAS: 113759-50-5

Cronidipine

Purity: ≥98%

Molecular weight: 598.04g/mol

Ref: 54-BUP07967

Cronidipine

CAS: 113759-50-5

Cronidipine (LF 20254), a calcium channel antagonist, is used potentially for the treatment of hypertension and myocardia ischemia.

Formula: C₃₀H₃₂ClN₃O₈

Purity: 99.47%

Color and Shape: Solid

Molecular weight: 598.04

Ref: TM-T27087